Mouse TFPI ELISA Kit sinobiological KIT50131
$400.00
In stock
SKU
KIT50131
| Catalog No. | Size | Price (USD) |
| KIT50131-1 | 1 Kit (96 Tests) | $414.71 |
General Information
| Product name | Mouse TFPI ELISA Kit |
| Specificity | This assay recognizes recombinant mouse TFPI. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Recombinant protein |
| Sensitivity | 3.85 pg/mL |
| Assay range | 15.63-1000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Mouse TFPI ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Mouse TFPI protein in Recombinant protein . It contains recombinant Mouse TFPI, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: A630013F22Rik ELISA Kit, Mouse; EPI ELISA Kit, Mouse; LACI ELISA Kit, Mouse; Tfpi ELISA Kit, Mouse
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Mouse TFPI ELISA Kit Standard Curve 127 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Mouse TFPI ELISA Kit Specificity 146 |
| Image 2 URL | Source image |
Background Information
| Full Name | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| Description | Tissue factor pathway inhibitor (TFPI) is the natural inhibitor of TF coagulant and signaling activities. It is a Kunitz-type serine proteinase inhibitor that down-regulates tissue factor-initiated blood coagulation. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypson inhibitor and bovin basic pancreatic trypsin inhibitor. TFPI is the natural inhibitor of TF coagulant and signaling activities. The importance of TFPI in the regulation of blood coagulation is emphasized by how its activity is modulated in human disease. In a factor (F) Xa-dependent feedback system, TFPI binds directly and inhibits the TF-FVII/FVIIa complex. Normally, TFPI exists in plasma both as a full-length molecule and as variably carboxy-terminal truncated forms. TFPI also circulates in complex with plasma lipoproteins. The levels and the dual inhibitor effect of TFPI on FXa and TF-FVII/FVIIa complex offers insight into the mechanisms of various pathological conditions triggered by TF. TFPI may play an important role in modulating TF-induced thrombogenesis and it may also provide a unique therapeutic approach for prophylaxis and/or treatment of various diseases. In addition, studies have shown that TFPI exhibits antiangiogenic and antimetastatic effects in vitro and in vivo. In animal models of experimental metastasis, both circulating and tumor cell-associated TFPI are shown to significantly reduce tumor cell-induced coagulation activation and lung metastasis. |
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