Human TIM-3/HAVCR2 ELISA Kit sinobiological KIT10390
$714.00
In stock
SKU
KIT10390
| Catalog No. | Size | Price (USD) |
| KIT10390-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Human TIM-3/HAVCR2 ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human TIMD3. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 16.5 pg/mL |
| Assay range | 39.06-2500 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human TIM-3/HAVCR2 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human TIM-3/HAVCR2 protein in Serum . It contains recombinant Human TIM-3/HAVCR2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
| Interference | Preparations of GST-Xa-Ab1/42 at 20 ng/mL in a mid-range recombinant human TIMD3 control were assayed for interference. No significant interference was observed. |
Synonyms: CD366 ELISA Kit, Human; FLJ14428 ELISA Kit, Human; HAVcr-2 ELISA Kit, Human; KIM-3 ELISA Kit, Human; SPTCL ELISA Kit, Human; Tim-3 ELISA Kit, Human; TIM3 ELISA Kit, Human; TIMD-3 ELISA Kit, Human; TIMD3 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human TIM-3/HAVCR2 ELISA Kit Standard Curve 61 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human TIM-3/HAVCR2 ELISA Kit Specificity 195 |
| Image 2 URL | Source image |
Background Information
| Full Name | hepatitis A virus cellular receptor 2 |
| Description | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response. |
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