| Catalog No. | Size | Price (USD) |
| 40591-V08H-1 | 1 mg | $5,603.03 |
| 40591-V08H-100 | 100 µg | $666.50 |
| 40591-V08H-300 | 300 µg | $231.05 |
General Information
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | > 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC. |
| Activity | 1. Measured by its binding ability in a functional ELISA. Immobilized human ACE2 protein (Fc tag)(Cat: 10108-H05H) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag) (40591-V08H), the EC 50 of SARS-CoV-2/2019-nCoV Spike Protein (S1 Subunit, His tag) (Cat: 40591-V08H) is 200-600 ng/mL. 2. Loaded ACE2 Protein, Human, Recombinant (mFc Tag) (Cat. No. 10108-H05H) on AMC Biosensor, can bind SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein (Cat. No. 40591-V08H) with an affinity constant of 47.7 nM as determined by Octet RED System. |
| Protein Construction | A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) spike protein S1 Subunit (YP_009724390.1) (Val16-Arg685) was expressed with a polyhistidine tag at the C-terminus. |
| Accession# | YP_009724390.1 |
| Expressed Host | HEK293 Cells |
| Species | SARS-CoV-2 |
| Predicted N Terminal | Val16 |
| Molecule Mass | The recombinant SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, His Tag) consists of 681 amino acids and predicts a molecular mass of 76.5 kDa. |
Image / Experimental Information
| Image 1 Alt Text | CoV spike Protein 29770 |
| Image 1 URL | Source image |
| Image 2 Alt Text | 2019-nCoV CoV spike Protein 29840 |
| Image 2 URL | Source image |
| Image 3 Alt Text | 2019-nCoV Coronavirus spike Protein 30135 |
| Image 3 URL | Source image |
| Image 4 Alt Text | SARS-CoV-2 Coronavirus spike Protein 33243 |
| Image 4 URL | Source image |
Background Information
| Description | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2 (angiotensin-converting enzyme 2), DPP4 (dipeptidyl peptidase-4), APN (aminopeptidase N), CEACAM (carcinoembryonic antigen-related cell adhesion molecule), Sia (sialic acid), O-ac Sia (O-acetylated sialic acid). The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate. |
| References |
|
[{"title":"Mass Spectrometry-Based Mapping of Conformational Epitopes on SARS-CoV-2 Antigens Targeted by Monoclonal Antibodies","authors":["Phumrapee Pianpaktr","Parawan Ramanandana","...","Patanachai K. Limpikirati"],"journal":"International Journal of Biological Macromolecules","date":"2026-08-01","pmid":"42324012","doi":""},{"title":"Salivary polyreactive and SARS-CoV-2-specific antibody responses following SARS-CoV-2 infection and vaccination in healthcare workers.","authors":["Mischa H Koenen","Juana Claus","...","Lilly M Verhagen"],"journal":"Clinical Immunology","date":"2026-07-28","pmid":"42521110","doi":"10.1016/j.clim.2026.110756"},{"title":"Persistent CD4 + T cell hyporesponsiveness during recovery from prolonged symptomatic SARS-CoV-2 infection.","authors":["Jadith Ziegler","Christina Lawrence","...","Susan Kovats"],"journal":"Cellular Immunology","date":"2026-06-15","pmid":"42320282","doi":"10.1016/j.cellimm.2026.105127"},{"title":"Antioxidant properties of Rhodiola rosea","authors":["Brink Drew F.","Sapp Tiara L.","...","Suzuki Yuichiro J."],"journal":"bioRxiv","date":"2026-05-22","pmid":"","doi":"10.64898/2026.05.21.726678"},{"title":"Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunity","authors":["Meifang Chen","Xiaojia Jiao","...","Bing He"],"journal":"Cell Reports Medicine","date":"2026-05-19","pmid":"42025165","doi":""},{"title":"Fc-mediated antibody functions are associated with disease severity in COVID-19.","authors":["Sungim Choi","Jong Su Kang","...","Seong Yeon Park"],"journal":"Frontiers in Immunology","date":"2026-05-18","pmid":"42148134","doi":"10.3389/fimmu.2026.1797975"},{"title":"SARS-CoV-2 Seroprevalence of Surinamese Children and Determinants of Seropositivity in the CCREOH/MeKiTamara Cohort.","authors":["Delmaliz Barreto-Vázquez","Jeanine M Buchanich","...","Maureen Y Lichtveld"],"journal":"Children (Basel, Switzerland)","date":"2026-05-04","pmid":"42073071","doi":""},{"title":"Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains","authors":["Michelle Lilly","Felicitas Ruiz","...","Carolyn B. Coyne"],"journal":"mBio","date":"2026-04-01","pmid":"41738780","doi":""},{"title":"Quantum dot conjugated virus spike protein for cell-based bio-sensing systems and drug screening","authors":["Eunkeu Oh","Kimihiro Susumu","...","Kirill Gorshkov"],"journal":"","date":"2026-03-31","pmid":"","doi":""},{"title":"Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein.","authors":["Chongyang Zhang","Peiwen Ding","...","Jianwei Wang"],"journal":"mBio","date":"2026-03-26","pmid":"41885456","doi":"10.1128/mbio.00129-26"},{"title":"Determinants of natural killer cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies","authors":["Delphine M. Depierreux","Felicitas Ruiz","...","Christopher F. Basler"],"journal":"PLoS Pathogens","date":"2026-03-12","pmid":"41818265","doi":""},{"title":"A smartphone-integrated aptasensor for SARS-CoV-2 S1 protein using multi-walled carbon nanotube-ionic liquid modified electrodes.","authors":["Huseyin Senturk","Arzum Erdem"],"journal":"Mikrochimica acta","date":"2026-03-04","pmid":"41775871","doi":"10.1007/s00604-026-07918-7"},{"title":"HKU1 Immune Imprinting Is Associated with Post-COVID Symptoms After SARS-CoV-2 Infection","authors":["Abdelilah Majdoubi","Christina Michalski","...","Pascal M. Lavoie"],"journal":"iScience","date":"2026-03-01","pmid":"","doi":"10.1016/j.isci.2026.115175"},{"title":"Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms","authors":["Zhendong Pan","Xu Zheng","...","Ping Zhao"],"journal":"NPJ vaccines","date":"2026-01-30","pmid":"41611712","doi":"10.1038/s41541-026-01383-2"},{"title":"Fusion protein pan-sarbecovirus vaccines elicit broadly protective immune responses targeting Clade 1a, 1b, and 3 sarbecoviruses","authors":["Alyson Kelvin","Matthew Rogers","...","Trina Racine"],"journal":"Research Square","date":"2026-01-28","pmid":"","doi":"10.21203/rs.3.rs-8544714/v1"},{"title":"Strong and early immune responses against SARS-CoV-2 in mice and rhesus macaques after BNT162b3 vaccination.","authors":["Annette B Vogel","Bonny G Lui","...","Uğur Şahin"],"journal":"NPJ vaccines","date":"2026-01-14","pmid":"41530185","doi":""},{"title":"Construction and transient expression of the Cap protein of porcine circovirus 3 in <i>Nicotiana benthamiana</i>","authors":[],"journal":"Vietnam Journal of Biotechnology","date":"2025-12-30","pmid":"","doi":"10.15625/vjbt-23481"},{"title":"Combinational adjuvants delivered by ink-jet potentiate naked mRNA vaccines for robust protection against infectious diseases","authors":["Qiao Nan","Ishikawa Junichi","...","Uchida Satoshi"],"journal":"bioRxiv","date":"2025-12-26","pmid":"","doi":"10.64898/2025.12.24.696305"},{"title":"Systemic and mucosal immune signatures of protection against SARS-CoV-2 transmission in humans","authors":["Amaya Rojo-Fernandez","Sadaf Aslam","...","Teresa Aydillo"],"journal":"Cell Reports Medicine","date":"2025-12-16","pmid":"41406942","doi":""},{"title":"Primary cilium and TULP3-dependent ciliary targeting of ACE2 in SARS-CoV-2 tropism.","authors":["Yun Hong Du","Wai Lam Tung","...","Catherine Hong Huan Hor"],"journal":"Cell Communication and Signaling : CCS","date":"2025-11-29","pmid":"41316318","doi":"10.1186/s12964-025-02519-y"},{"title":"A longitudinal study of antibody responses to endemic HCoV and novel SARS-CoV-2 among mother-child pairs in Zambia.","authors":["Natasha Makabilo Laban","Martin Rhys Goodier","...","Samuel Bosomprah"],"journal":"BMC Infectious Diseases","date":"2025-11-19","pmid":"41254508","doi":""},{"title":"Production of Clinical-Grade SARS-CoV-2 Spike Ferritin Nanoparticle Protein Immunogen by Transient Transfection.","authors":["Agnes Hajduczki","William C Chang","...","Stasya Zarling"],"journal":"Vaccines","date":"2025-10-28","pmid":"41150429","doi":"10.3390/vaccines13101041"},{"title":"Smartphone-Integrated User-Friendly Electrochemical Biosensor Based on Optimized Aptamer Specific to SARS-CoV-2 S1 Protein","authors":[],"journal":"Sensors","date":"2025-10-25","pmid":"","doi":"10.3390/s25216579"},{"title":"Associations between food consumption with T cell activation and antibody responses following SARS-CoV-2 mRNA vaccination","authors":["Hiroki Negishi","Gaku Nakato","...","Shinji Fukuda"],"journal":"Gut Microbes Reports","date":"2025-10-25","pmid":"41909898","doi":"10.1080/29933935.2025.2568927"},{"title":"SARS-CoV-2 Antibody Levels and Infections in Multiple Vaccinated Employees Over Time.","authors":["Ingrid Sander","Sabine Kespohl","...","Monika Raulf"],"journal":"Journal of medical virology","date":"2025-10-18","pmid":"41108558","doi":"10.1002/jmv.70628"},{"title":"Circular mRNA against CleanCap linear mRNA vectors: comprehensive comparison, expression, active and passive immunization","authors":["Vakhtinskii Vladimir M.","Tutykhina Irina L.","...","Gintsburg Alexander L."],"journal":"bioRxiv","date":"2025-10-14","pmid":"","doi":"10.1101/2025.10.13.682008"},{"title":"Inhaled booster vaccination with an MVA-based SARS-CoV-2 vaccine candidate induces T cell responses in lung","authors":["Hammerschmidt Swantje I.","Jauregui Rodrigo Gutierrez","...","Förster Reinhold"],"journal":"medRxiv","date":"2025-10-13","pmid":"","doi":"10.1101/2025.10.09.25337642"},{"title":"Devices and methods for treating a coronavirus infection and symptoms thereof","authors":["Charles J. Fisher, Jr.","Rosalia De Necochea Campion","...","Michael Jacobs"],"journal":"","date":"2025-09-09","pmid":"","doi":""},{"title":"Pediatric T cell and B cell responses to SARS-CoV-2 infection.","authors":["L Benjamin Hills","Numana Bhat","...","Shane Crotty"],"journal":"JCI insight","date":"2025-09-04","pmid":"40906527","doi":"10.1172/jci.insight.196032"},{"title":"Nano antibody for neutralizing toxicity of SARS-CoV-2 and preparation method and application thereof","authors":["Wenchao Zhuang","Fusheng Li","...","Yunxing Zhao"],"journal":"","date":"2025-08-26","pmid":"","doi":""},{"title":"Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates","authors":["Benoît Levast","Jérémie Becker","...","Laetitia Henaff"],"journal":"NPJ vaccines","date":"2025-07-29","pmid":"40730842","doi":"10.1038/s41541-025-01226-6"},{"title":"The quantity and quality of B-cell immunity against SARS-CoV-2 in children with cancer and hematological diseases","authors":["Eva Tiselius","Emil Sundberg","...","Anna Nilsson"],"journal":"Frontiers in Immunology","date":"2025-07-02","pmid":"40672943","doi":"10.3389/fimmu.2025.1613778"},{"title":"Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo","authors":["Ju Hyeong Jeon","Huabin Zhu","...","Xinle Cui"],"journal":"International Journal of Nanomedicine","date":"2025-07-01","pmid":"","doi":"10.2147/ijn.s527822"},{"title":"The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cells","authors":["Nathan Stasko","Leslee Arwood","...","Andrew Pekosz"],"journal":"mSphere","date":"2025-06-01","pmid":"40434113","doi":"10.1128/msphere.00230-25"},{"title":"Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines.","authors":["Lu Wang","Yanhong Sun","...","Chunhai Fan"],"journal":"Nano-Micro Letters","date":"2025-05-28","pmid":"40434536","doi":""},{"title":"Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike protein","authors":["Soo Ji Kim","Taewoo Kim","...","Manki Song"],"journal":"Scientific Reports","date":"2025-05-28","pmid":"40436929","doi":""},{"title":"Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson's disease.","authors":["Cara Sophie Schreiber","Lucas Navarro Ramil","...","Franziska Richter"],"journal":"Brain, behavior, and immunity","date":"2025-05-20","pmid":"40404020","doi":"10.1016/j.bbi.2025.05.021"},{"title":"Endemic coronavirus infection is associated with SARS-CoV-2 Fc receptor-binding antibodies.","authors":["David J Bean","Yan Mei Liang","...","Manish Sagar"],"journal":"Journal of virology","date":"2025-05-19","pmid":"40387363","doi":""},{"title":"Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in contrived dried blood spots and oral fluids","authors":["Kate L. DeRosa","Nora Pisanic","...","Dean D. Erdman"],"journal":"Microbiology Spectrum","date":"2025-05-01","pmid":"40130863","doi":""},{"title":"CXCL13/CXCR5 Chemokine Axis Promotes CXCR5 + CD19 + B-Cell and Follicular/Effector CXCR5 + CD4 + T-Cell Responses in the Lungs Associated with Protection from Severe and Fatal COVID-19 Following Infection with Pathogenic SARS-CoV-2 Delta Variant","authors":["Vahed Hawa","Chentoufi Aziz","...","BenMohamed Lbachir"],"journal":"bioRxiv","date":"2025-04-22","pmid":"","doi":"10.1101/2025.04.18.649623"},{"title":"Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: A prospective observational cohort study.","authors":["Kieran Ayling","Hannah Jackson","...","Kavita Vedhara"],"journal":"Brain, behavior, and immunity","date":"2025-03-11","pmid":"40081776","doi":"10.1016/j.bbi.2025.03.011"},{"title":"RaptGen-Assisted Generation of an RNA/DNA Hybrid Aptamer against SARS-CoV-2 Spike Protein","authors":["Tatsuo Adachi","Shigetaka Nakamura","...","Yoshikazu Nakamura"],"journal":"Biochemistry","date":"2025-03-08","pmid":"38457656","doi":""},{"title":"SARS-CoV-2 Spike S1 Subunit Triggers Pericyte and Microvascular Dysfunction in Human Pancreatic Islets","authors":["Catarina Andrade Barboza","Luciana Mateus Gonçalves","...","Joana Almaça"],"journal":"Diabetes","date":"2025-03-01","pmid":"39715591","doi":"10.2337/db24-0816"},{"title":"Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant","authors":["L. Carissa Aurelia","Ruth A. Purcell","...","Amy W. Chung"],"journal":"Science Advances","date":"2025-02-28","pmid":"","doi":"10.1126/sciadv.ads1482"},{"title":"Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice.","authors":["Dylan T Boehm","Kaitlyn M Landreth","...","Tracy W Liu"],"journal":"Scientific Reports","date":"2025-02-18","pmid":"39948424","doi":"10.1038/s41598-025-89930-0"},{"title":"BA.1 breakthrough infection elicits distinct antibody and memory B cell responses in vaccinated-only versus hybrid immunity individuals","authors":["Carla Saade","Timothée Bruel","...","Antonin Bal"],"journal":"iScience","date":"2025-02-05","pmid":"","doi":""},{"title":"High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents","authors":["Marloes I Hofstee","Joanna Kaczorowska","...","Anne-Marie Buisman"],"journal":"Immunity & ageing : I & A","date":"2025-01-02","pmid":"","doi":"10.1186/s12979-024-00495-4"},{"title":"Light-responsive bifunctional crosslinker enables facile preparation of antifouling sensor array for immunodetection of viral antigens","authors":["Shijie Sun","Yancao Chen","...","Xiao-Bing Zhang"],"journal":"Sensors and Actuators B: Chemical","date":"2025-01-01","pmid":"","doi":"10.1016/j.snb.2024.136570"},{"title":"Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals","authors":["Najwa D. Aljehani","Levi Tamming","...","Swati Jain"],"journal":"mBio","date":"2025-01-01","pmid":"39629990","doi":""},{"title":"Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin L","authors":["Keyu Guo","Baoqing You","...","Shuyi Si"],"journal":"Bio-protocol","date":"2025-01-01","pmid":"","doi":"10.21769/bioprotoc.5400"},{"title":"Ultra-high sensitivity optical fiber SARS-CoV-2 biosensor based on triangular gold nanosheets/gold film coupling enhancement","authors":["Bing Xu","Xiaoying Xiang","...","Jianglou Huang"],"journal":"Optical Materials","date":"2025-01-01","pmid":"","doi":"10.1016/j.optmat.2025.116646"},{"title":"Dose-dependent serological profiling of AdCLD-CoV19-1 vaccine in adults.","authors":["Jung Hyuk Lee","Yuna Shin","...","Manki Song"],"journal":"mSphere","date":"2024-12-26","pmid":"39723823","doi":""},{"title":"Effect of Fusion to the LTB Carrier Protein on Coronavirus Spike Protein Vaccine Candidates Produced in Maize","authors":["Erin Egelkrout","Magdalena Maj","...","John Howard"],"journal":"Viruses","date":"2024-12-24","pmid":"","doi":"10.3390/v17010007"},{"title":"Co-adjuvanting Nod2-stimulating bacteria with a TLR7 agonist elicits potent protective immunity against respiratory virus infection.","authors":["Sujin An","Jeein Oh","...","Donghyun Kim"],"journal":"International journal of antimicrobial agents","date":"2024-12-13","pmid":"39477030","doi":"10.1016/j.ijantimicag.2024.107369"},{"title":"Quantitating SARS-CoV-2 neutralizing antibodies from human dried blood spots","authors":["Katherine Berman","Greta Van Slyke","...","Elias A. Rahal"],"journal":"Microbiology Spectrum","date":"2024-12-01","pmid":"39470282","doi":"10.1128/spectrum.00846-24"},{"title":"Innate immune response after BNT162b2 COVID-19 vaccination associates with reactogenicity","authors":["Catharina E. van Ewijk","Sara Suárez Hernández","...","Martijn D.B. van de Garde"],"journal":"Vaccine: X","date":"2024-12-01","pmid":"","doi":"10.1016/j.jvacx.2024.100593"},{"title":"Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire","authors":["Evan R. Abt","Alex K. Lam","...","Ting-Ting Wu"],"journal":"Proceedings of the National Academy of Sciences of the United States of America","date":"2024-11-26","pmid":"39589869","doi":""},{"title":"The comparison of the Sensitivity Value of Gold Nanoparticles (AuNPs) between ANTAM and Commercial Gold Sources in the Detection of SARS-CoV-2: A Preliminary Study","authors":[],"journal":"Molekul","date":"2024-11-24","pmid":"","doi":"10.20884/1.jm.2024.19.3.11037"},{"title":"Sulfated Cellulose Nanofiber Hydrogel with Mucus-Like Activities for Virus Inhibition.","authors":["Yanping Long","Mathias Dimde","...","Chuanxiong Nie"],"journal":"ACS Applied Materials & Interfaces","date":"2024-11-24","pmid":"39582136","doi":"10.1021/acsami.4c17998"},{"title":"Early immune profiling reveals distinct inflammatory responses between children and adults few days after primary SARS-CoV-2 infection","authors":["Martijn D. B. Van de Garde","Alberto Miranda-Bedate","...","Elena Pinelli"],"journal":"Frontiers in Immunology","date":"2024-11-18","pmid":"39624095","doi":"10.3389/fimmu.2024.1359993"},{"title":"Impaired mucosal IgA response in patients with severe COVID-19.","authors":["Melyssa Yaugel-Novoa","Blandine Noailly","...","Stéphane Paul"],"journal":"Emerging microbes & infections","date":"2024-10-03","pmid":"39358866","doi":"10.1080/22221751.2024.2401940"},{"title":"A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT)","authors":["Brien K. Haun","Albert To","...","Axel T. Lehrer"],"journal":"Immuno","date":"2024-09-29","pmid":"","doi":"10.3390/immuno4010007"},{"title":"[2409.15489] An integrated evanescent-field biosensor in silicon","authors":[" Mohammed A. Al-Qadasi"," Samantha M. Grist","..."," Sudip Shekhar"],"journal":"","date":"2024-09-23","pmid":"","doi":"10.48550/arxiv.2409.15489"},{"title":"Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families","authors":["Matthew J. Vukovich","Andrea R. Shiakolas","...","David T. Evans"],"journal":"PLoS Pathogens","date":"2024-09-18","pmid":"","doi":"10.1371/journal.ppat.1012499"},{"title":"Discovery and characterization of a pan-betacoronavirus S2-binding antibody.","authors":["Nicole V Johnson","Steven C Wall","...","Ivelin S Georgiev"],"journal":"Structure (London, England : 1993)","date":"2024-09-15","pmid":"39326419","doi":""},{"title":"Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults","authors":["Anne T. Gelderloos","Marije K. Verheul","...","Puck B. van Kasteren"],"journal":"Immunity & ageing : I & A","date":"2024-09-14","pmid":"39272189","doi":""},{"title":"Long-Term Immunity against SARS-CoV-2 Wild-Type and Omicron XBB.1.5 in Indonesian Residents after Vaccination and Infection.","authors":[" Karismananda","Ammar Abdurrahman Hasyim","...","Yenni Yusuf"],"journal":"Antibodies (Basel, Switzerland)","date":"2024-09-02","pmid":"39311377","doi":""},{"title":"P-selectin Facilitates SARS-CoV-2 Spike 1 Subunit Attachment to Vesicular Endothelium and Platelets.","authors":["Cheng Wang","Shaobo Wang","...","Junping Wang"],"journal":"ACS Infectious Diseases","date":"2024-08-09","pmid":"38912949","doi":"10.1021/acsinfecdis.3c00728"},{"title":"Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo.","authors":["Yen-Ling Liu","Tzu-Yi Liao","...","Tian-Lu Cheng"],"journal":"Biomaterials Research","date":"2024-08-07","pmid":"39665081","doi":""},{"title":"Mild and moderate COVID-19 during Alpha, Delta and Omicron pandemic waves in urban Maputo, Mozambique, December 2020-March 2022: A population-based surveillance study","authors":["Brecht Ingelbeen","Victória Cumbane","...","Nei-yuan Hsiao"],"journal":"PLOS Global Public Health","date":"2024-08-05","pmid":"39102391","doi":"10.1371/journal.pgph.0003550"},{"title":"The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2","authors":["Jamie Guenthoer","Meghan E. Garrett","...","Catarina E. Hioe"],"journal":"PLoS Pathogens","date":"2024-08-02","pmid":"39093891","doi":"10.1371/journal.ppat.1012383"},{"title":"Primary SARS‐CoV‐2 infection in children and adults results in similar Fc‐mediated antibody effector function patterns","authors":["Anne T Gelderloos","Anke J Lakerveld","...","Puck B van Kasteren"],"journal":"Clinical & Translational Immunology","date":"2024-07-26","pmid":"","doi":"10.1002/cti2.1521"},{"title":"Single-particle rotational sensing for analyzing the neutralization activity of antiviral antibodies.","authors":["Jinhui Shang","Huiwen Li","...","Bin Xiong"],"journal":"Talanta","date":"2024-07-25","pmid":"39089080","doi":"10.1016/j.talanta.2024.126606"},{"title":"Beta-spike-containing boosters induce robust and functional antibody responses to SARS-CoV-2 in macaques primed with distinct vaccines","authors":["Yixiang Deng","Caroline Atyeo","...","Ryan P. McNamara"],"journal":"Cell Reports","date":"2024-07-25","pmid":"38007686","doi":""},{"title":"Could Ocular Glands Be Infected by SARS-CoV-2?","authors":["Jinghua Bu","Minjie Zhang","...","Christian Barbato"],"journal":"Diseases","date":"2024-07-25","pmid":"39195168","doi":"10.3390/diseases12080169"},{"title":"Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies.","authors":["Si Chen","Zhengyuan Zhang","...","Ling Chen"],"journal":"Signal transduction and targeted therapy","date":"2024-07-22","pmid":"39039046","doi":"10.1038/s41392-024-01906-0"},{"title":"Phenylboronic Acid-Modified Membrane-Like Magnetic Quantum Dots Enable the Ultrasensitive and Broad-Spectrum Detection of Viruses by Lateral Flow Immunoassay.","authors":["Chongwen Wang","Qing Yu","...","Bing Gu"],"journal":"ACS Nano","date":"2024-07-02","pmid":"38901038","doi":"10.1021/acsnano.4c01824"},{"title":"Discovery of a novel inhibitor of macropinocytosis with antiviral activity.","authors":["Bartlomiej Porebski","Wanda Christ","...","Oscar Fernandez-Capetillo"],"journal":"Molecular therapy : the journal of the American Society of Gene Therapy","date":"2024-07-02","pmid":"38956870","doi":"10.1016/j.ymthe.2024.06.038"},{"title":"Sex-biased immunogenicity of a mucosal subunit vaccine against SARS-CoV-2 in mice.","authors":["Jianping Li","Kevin S Hsu","...","Yongjun Sui"],"journal":"Frontiers in Immunology","date":"2024-06-05","pmid":"38835757","doi":"10.3389/fimmu.2024.1386243"},{"title":"SARS‐CoV‐2 Seroprevalence Trends in the Netherlands in the Variant of Concern Era: Input for Future Response","authors":["Eric R. A. Vos","Cheyenne C. E. van Hagen","...","Hester E. de Melker"],"journal":"Influenza and Other Respiratory Viruses","date":"2024-06-04","pmid":"38837866","doi":"10.1111/irv.13312"},{"title":"Developing lateral flow immunochromatography (LFIA) peptide-based test strips for rapid detection of antigens and antibodies against specific antigens","authors":["Charlotte A. E. Hauser","Panagiotis Bilalis","...","Rosario Perez Pedroza"],"journal":"","date":"2024-05-28","pmid":"","doi":""},{"title":"Clinical validation of SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex.","authors":["Viviana Vásquez","Jahir Orozco"],"journal":"Journal of virological methods","date":"2024-05-27","pmid":"38608761","doi":"10.1016/j.jviromet.2024.114940"},{"title":"Rapid and simple viral protein detection by functionalized 2D MoS 2 /graphene electrochemiluminescence aptasensor.","authors":["Laura Gutiérrez-Gálvez","Hanaa El Hajioui-El Ghalbzouri","...","Encarnación Lorenzo"],"journal":"Talanta","date":"2024-05-20","pmid":"38788383","doi":"10.1016/j.talanta.2024.126293"},{"title":"Protein structure, a genetic encoding for glycosylation","authors":["Kellman Benjamin P.","Sandoval Daniel","...","Lewis Nathan E."],"journal":"bioRxiv","date":"2024-05-15","pmid":"","doi":"10.1101/2024.05.15.594261"},{"title":"Non-cross-reactive epitopes dominate the humoral immune response to COVID-19 vaccination – kinetics of plasma antibodies, plasmablasts and memory B cells","authors":["Kilian A. Wietschel","Kevin Fechtner","...","Silva Holtfreter"],"journal":"Frontiers in Immunology","date":"2024-05-14","pmid":"38807606","doi":"10.3389/fimmu.2024.1382911"},{"title":"Intratumoral administration of mRNA-1273 vaccine delays melanoma growth in mice","authors":["Boehm Dylan T.","Landreth Kaitlyn M.","...","Liu Tracy W."],"journal":"bioRxiv","date":"2024-05-10","pmid":"","doi":"10.1101/2024.05.06.592840"},{"title":"PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females","authors":["Ethan B. Jansen","Ali Toloue Ostadgavahi","...","Alyson A. Kelvin"],"journal":"Scientific Reports","date":"2024-04-29","pmid":"38684819","doi":"10.1038/s41598-024-60089-4"},{"title":"Bergenia purpurascens is a non-specific ACE2 inhibitor","authors":["Yongxia Shi","Xiaoning Sun","...","Lei Jiang"],"journal":"Europe PMC","date":"2024-04-22","pmid":"","doi":"10.21203/rs.3.rs-4148484"},{"title":"A novel nanoliposome model platform mimicking SARS-CoV-2 as a bioreceptor to dissect the amperometric response in biosensor applications.","authors":["Füsun Kazancı","M Samet Kılıç","...","R Seda Tığlı Aydın"],"journal":"International Journal of Biological Macromolecules","date":"2024-04-08","pmid":"38437936","doi":"10.1016/j.ijbiomac.2024.130530"},{"title":"Utilizing noncatalytic ACE2 protein mutant as a competitive inhibitor to treat SARS-CoV-2 infection","authors":["Shengjiang Liu","Haifeng Chen","...","Li Ou"],"journal":"Frontiers in Immunology","date":"2024-04-05","pmid":"","doi":"10.3389/fimmu.2024.1365803"},{"title":"Protective mucosal SARS-CoV-2 antibodies in the majority of the general population in the Netherlands.","authors":["Marije K Verheul","Joanna Kaczorowska","...","Gerco den Hartog"],"journal":"Mucosal immunology","date":"2024-03-27","pmid":"38553008","doi":"10.1016/j.mucimm.2024.03.008"},{"title":"Immunological Response to Subcutaneous and Intranasal Administration of SARS-CoV-2 Spike Protein in Mice","authors":["Mao Kinoshita","Kentaro Muranishi","...","Ravinder Kumar"],"journal":"Vaccines","date":"2024-03-22","pmid":"38675726","doi":""},{"title":"Broad Epitope Coverage of Therapeutic Multi-Antibody Combinations Targeting SARS-CoV-2 Boosts In Vivo Protection and Neutralization Potency to Corner an Immune-Evading Virus.","authors":["Ilse Roodink","Maartje van Erp","...","Yasmina N Abdiche"],"journal":"Biomedicines","date":"2024-03-13","pmid":"38540255","doi":""},{"title":"Dual-Modal Colorimetric and Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunoassay for Ultrasensitive Detection of SARS-CoV-2 Using a Plasmonic Gold Nanocrown","authors":["Supriya Atta","Yuanhao Zhao","...","Tuan Vo-Dinh"],"journal":"Analytical Chemistry","date":"2024-03-12","pmid":"pm38471066","doi":""},{"title":"Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants","authors":["Paola A. Lopez","Nadège Nziza","...","Andrea G. Edlow"],"journal":"iScience","date":"2024-02-20","pmid":"","doi":"10.1016/j.isci.2024.109273"},{"title":"Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection","authors":["Fan Zhou","Juha Vahokoski","...","Camilla Tøndel"],"journal":"NPJ vaccines","date":"2024-02-20","pmid":"","doi":"10.1038/s41541-024-00817-z"},{"title":"Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study","authors":["John S. Kim","Yifei Sun","...","Elizabeth C. Oelsner"],"journal":"Nature Communications","date":"2024-02-19","pmid":"38374032","doi":"10.1038/s41467-024-45468-9"},{"title":"Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties.","authors":["Jeong-Chan Lee","Su Yeong Kim","...","Donald E Ingber"],"journal":"Nature Communications","date":"2024-02-14","pmid":"38331881","doi":"10.1038/s41467-024-44822-1"},{"title":"Variability in Severe Acute Respiratory Syndrome Coronavirus 2 IgG Antibody Affinity to Omicron and Delta Variants in Convalescent and Community mRNA-Vaccinated Individuals","authors":["Michael K. Tu","Samantha H. Chiang","...","Charles M. Strom"],"journal":"ImmunoHorizons","date":"2024-01-31","pmid":"35618268","doi":""},{"title":"Ad5-nCoV Vaccination Could Induce HLA-E Restricted CD8 + T Cell Responses Specific for Epitopes on Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein.","authors":["Yuling Wang","Lu Yang","...","Ying Ma"],"journal":"Viruses","date":"2024-01-24","pmid":"38257752","doi":"10.3390/v16010052"}]
