| Catalog No. | Size | Price (USD) |
| C40-18CG-10 | 10 µg | $515.43 |
| C40-18CG-50 | 50 µg | $1,729.93 |
| C40-18CG-500 | 500 µg | $3,907.16 |
General Information
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25-1.0mM DTT, 0-0.1mM PMSF, 10-25% glycerol Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Stability & Storage | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Purity | For specific information on a given lot, see related technical data sheet. |
| Activity | For specific information on a given lot, see related technical data sheet. |
| Protein Construction | Recombinant full length human CDK9 and CyclinT1 proteins were co-expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. |
| Expressed Host | Baculovirus-Insect Cells |
| Species | Human |
| Molecule Mass | CDK9 ~68 kDa; CyclinT1 ~110 kDa |
| Technical Data Sheet by Lot # | J5287-18 J5301-1 P5516-10 SCF19AP2731 Y4280-5 |
Image / Experimental Information
| Image 1 Description | Determination of ATP Km for recombinant protein kinases CDK9/CyclinT1-Cat. No.: C40-18CG) using ADP-GloTM Assay. With saturating substrate concentration, the relative luminescence values were plotted against various ATP concentrations. The Michaelis-Menten equation was then used to generate the Km values. (Validation Experiment) |
| Image 1 Alt Text | Human CDK9 & Cyclin T1 Protein 48801 |
| Image 1 URL | Source image |
title: Structure-Guided Discovery of a Bis-Pyridyl Diamine-Based Dual CDK7/9 Inhibitor with In Vitro and In Vivo Antitumor Efficacy in Glioblastoma Multiforme.
authors: Nithya Sree Pr; Tejaswi Somarowthu; ...; Sandip B Bharate
journal: ACS Chemical Neuroscience
date: 2026-05-14
pmid: 42133861
doi: 10.1021/acschemneuro.6c00105
cited_by_count: 0
bioz_score: 94
title: TRMT6‐Mediated m 1 A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma
authors: Rui Zhang; Dandan Zong; ...; Peng Hou
journal: Advanced Science
date: 2026-04-20
pmid: 42003777
doi: 10.1002/advs.202514172
cited_by_count: 0
techniques: Amplification; Binding Assay; Centrifugation; ChIP-qPCR; Co-Immunoprecipitation Assay; Control; Expressing; Immunohistochemistry; In Vitro; Incubation; Inhibition; Kinase Assay; Knock-Out; Luciferase; Lysis; Modification; Mutagenesis; Over Expression; Phospho-proteomics; Plasmid Preparation; Quantitative RT-PCR; Recombinant; Sequencing; Transfection; Variant Assay; Western Blot
bioz_score: 94
title: Identification of mitoxantrone as a potent inhibitor of CDK7/Cyclin H via structure-based virtual screening and In-Vitro validation by ADP-Glo kinase assay.
authors: Tejaswi Somarowthu; Rohan R Patekar; Sandip B Bharate
journal: Bioorganic chemistry
date: 2025-01-22
pmid: 39787913
doi: 10.1016/j.bioorg.2024.108111
cited_by_count: 4
techniques: Activity Assay; Kinase Assay
bioz_score: 94
MDSD
