| Catalog No. | Size | Price (USD) |
| E27-122EG-10 | 10 µg | $500.61 |
| E27-122EG-50 | 50 µg | $1,715.12 |
| E27-122EG-500 | 500 µg | $3,788.68 |
General Information
| Validated applications | Kinase Assay |
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25-1.0mM DTT, 0-0.1mM PMSF, 10-25% glycerol Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Stability & Storage | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Purity | For specific information on a given lot, see related technical data sheet. |
| Activity | For specific information on a given lot, see related technical data sheet. |
| Protein Construction | Recombinant human HER2 (L755S) (676-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Expressed Host | Baculovirus-Insect Cells |
| Species | Human |
| Molecule Mass | ~116 kDa |
| Technical Data Sheet by Lot # | A4711-4 |
Synonyms: c-ERB-2 Protein, Human; c-ERB2 Protein, Human; CD340 Protein, Human; HER-2 Protein, Human; HER-2/neu Protein, Human; HER2 Protein, Human; MLN 19 Protein, Human; MLN-19 Protein, Human; MLN19 Protein, Human; NEU Protein, Human; NGL Protein, Human; p185(erbB2) Protein, Human; TKR1 Protein, Human; VSCN2 Protein, Human
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 2 |
| Description | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
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| References |
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title: A High-Sensitivity, Bluetooth-Enabled PCB Biosensor for HER2 and CA15-3 Protein Detection in Saliva: A Rapid, Non-Invasive Approach to Breast Cancer Screening.
authors: Hsiao-Hsuan Wan; Chao-Ching Chiang; ...; Josephine F Esquivel-Upshaw
journal: Biosensors
date: 2025-06-25
pmid: 40558468
cited_by_count: 2
techniques: Biomarker Discovery; In Situ; Plasmid Preparation
bioz_score: 93
title: Combined Morphological and Spectroscopic Diagnostic of HER2 Expression in Breast Cancer Tissues Based on Label-Free Surface-Enhanced Raman Scattering.
authors: Wenbo Mo; Qi Ke; ...; Zongqing Zhao
journal: Analytical Chemistry
date: 2023-02-08
pmid: 36706440
doi: 10.1021/acs.analchem.2c05067
cited_by_count: 5
techniques: Concentration Assay; Incubation; Molecular Weight; Recombinant
bioz_score: 93
title: Optically Responsive Protein Coating of DNA Origami for Triggered Antigen Targeting.
authors: Iris Seitz; Heini Ijäs; ...; Mauri A Kostiainen
journal: ACS Applied Materials & Interfaces
date: 2022-09-07
pmid: 35984232
doi: 10.1021/acsami.2c10058
cited_by_count: 13
techniques: Binding Assay; Blocking Assay; Comparison; Concentration Assay; Conjugation Assay; Control; Electrophoretic Mobility Shift Assay; Fast Protein Liquid Chromatography; Fluorescence; Incubation; Irradiation; Labeling; Microscopy; Polyacrylamide Gel Electrophoresis; Purification; SDS Page; Staining; Standard Deviation; Transmission Assay
bioz_score: 93
title: Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity.
authors: Lei Wang; Xusha Zhou; ...; Grace Guoying Zhou
journal: Journal of Nanobiotechnology
date: 2021-07-29
pmid: 33109196
cited_by_count: 16
techniques: Binding Assay; Control; Enzyme-linked Immunosorbent Assay; Expressing; Incubation; Inhibition; Isolation; Marker; Plasmid Preparation; Produced; Purification; Stable Transfection; Standard Deviation; Transfection; Western Blot
bioz_score: 93
title: Detection and destruction of HER2-positive cancer cells by Ultra Quenchbody-siRNA complex.
authors: Jinhua Dong; Yuya Oka; ...; Hiroshi Ueda
journal: Biotechnology and bioengineering
date: 2021-07-12
pmid: 32039472
doi: 10.1002/bit.27302
cited_by_count: 24
techniques: Clone Assay; Expressing; Modification
bioz_score: 93
title: Magnetic nanocarriers for the specific delivery of siRNA: Contribution of breast cancer cells active targeting for down-regulation efficiency.
authors: J Bruniaux; E Allard-Vannier; ...; S David
journal: International Journal of Pharmaceutics
date: 2020-01-30
pmid: 31352052
doi: 10.1016/j.ijpharm.2019.118572
cited_by_count: 26
techniques: Agarose Gel Electrophoresis; Enzyme-linked Immunosorbent Assay; Incubation
bioz_score: 93
title: In Vitro Characterization and Stability Profiles of Antibody–Fluorophore Conjugates Derived from Interchain Cysteine Cross-Linking or Lysine Bioconjugation
authors: Camille Martin; Guillaume Brachet; ...; Nicolas Joubert
journal: Pharmaceuticals
date: 2019-12-02
pmid: 31810248
doi: 10.3390/ph12040176
pmcid: 6958397
cited_by_count: 12
techniques: Binding Assay; Enzyme-linked Immunosorbent Assay; Incubation; Indirect ELISA
bioz_score: 93
title: Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer
authors: Changliang Liu; Houqian Gao; ...; Yanlian Yang
journal: Journal of Materials Chemistry B
date: 2019-01-01
doi: 10.1039/c9tb00433e
cited_by_count: 39
techniques: Colorimetric Assay; Labeling; Magnetic Beads; Synthesized
bioz_score: 93
title: Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer
authors: Marlies Gijs; Gregory Penner; ...; Alfredo Berzal-Herranz
journal: Pharmaceuticals
date: 2016-05-19
pmid: 27213406
doi: 10.3390/ph9020029
pmcid: 4932547
cited_by_count: 53
techniques: Binding Assay; Cell Culture; Concentration Assay; Expressing; Flow Cytometry; Fluorescence; Imaging; Incubation; Injection; Microscopy; Negative Control; Protein Binding; SPR Assay; Selection; Staining
bioz_score: 93
title: HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
authors: Lingling Geng; Zihua Wang; ...; Qiaojun Fang
journal: Theranostics
date: 2016-01-01
pmid: 27279916
doi: 10.7150/thno.14302
pmcid: 4893650
cited_by_count: 41
techniques: Binding Assay; Expressing; Flow Cytometry; Fluorescence; Immunocytochemistry; In Situ; Labeling; Purification; Sequencing; Staining
bioz_score: 93
title: Element labeling of antibody fragments for ICP-MS based immunoassays
authors: Teresa Mairinger; Gordana Wozniak-Knopp; ...; Stephan Hann
journal: Journal of Analytical Atomic Spectrometry
date: 2016-01-01
doi: 10.1039/c6ja00252h
cited_by_count: 7
techniques: Injection; Size-exclusion Chromatography
bioz_score: 93
title: Covalent conjugation of cysteine-engineered scFv to PEGylated magnetic nanoprobes for immunotargeting of breast cancer cells
authors: Christophe Alric; Nicolas Aubrey; ...; Katel Hervé-Aubert
journal: RSC Advances
date: 2016-01-01
doi: 10.1039/c6ra06076e
cited_by_count: 0
techniques: Enzyme-linked Immunosorbent Assay; Expressing
bioz_score: 93
title: Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
authors: Lingling Geng; Zihua Wang; ...; Qiaojun Fang
journal: Theranostics
date: 2015-01-01
pmid: 26284145
doi: 10.7150/thno.12398
pmcid: 4533098
cited_by_count: 32
techniques: Binding Assay; Concentration Assay; Expressing; Flow Cytometry; Fluorescence; Imaging; Injection; Labeling; Protein Binding; Purification; Residue; SPR Assay; Sequencing
bioz_score: 93
title: Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.
authors: Sang Taek Jung; William Kelton; ...; George Georgiou
journal: ACS chemical biology
date: 2014-12-18
pmid: 23030766
doi: 10.1021/cb300455f
cited_by_count: 39
techniques: Binding Assay; Control; Enzyme-linked Immunosorbent Assay; Incubation; Injection; Purification; Serial Dilution
bioz_score: 93
title: Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2-positive Breast Cancer Cells in Vitro
authors: Zhe Liu; Jin-Hong Duan; ...; Xian-Da Yang
journal: Journal of Translational Medicine
date: 2012-07-20
pmid: 22817844
doi: 10.1186/1479-5876-10-148
pmcid: 3583217
cited_by_count: 137
techniques: Binding Assay; Concentration Assay; Confocal Microscopy; Flow Cytometry; Fluorescence; Generated; Incubation; Labeling; MTS Assay; Magnetic Beads; Selection; Sequencing
bioz_score: 93
MDSD
