| Catalog No. | Size | Price (USD) |
| 204876-T08-50 | 50 µL | $147.96 |
| 204876-T08-100 | 100 µL | $251.64 |
| 204876-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CDX1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CDX1 |
| Immunogen | E. coli-derived Human CDX1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CDX1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CDX1 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CDX1 Immunohistochemistry(IHC) 25297 |
| Image 1 URL | Source image |
Background Information
| Description | The caudal-related homeobox protein 1 (CDX1) is a transcription factor that is involved in the modulation of a variety of processes including proliferation, apoptosis, cell-adhesion, and columnar morphology. CDX1 is a primary controller of enterocyte differentiation and its expression is necessary for the transcriptional regulation of a large number of intestine-specific genes required for the intestine development, differentiation, and maintenance of the intestinal phenotype. Several markers of differentiation, including villin and cytokeratin 20, have been shown to be directly transcriptionally regulated by CDX1. Loss of differentiation is known to occur during cancer progression and, in colon cancer, the loss of villin has been associated with poor survival. There is evidence of the loss or down-regulation of CDX1 expression in colon cancer tumors and cell lines. |
| References |
|
title: The Involvement of CXCL17-GPR35 in Gastric Cancer Initiation and Development
authors: Yi-zhi Li; Ao-ran Liu; ...; Qian Xu
journal: Europe PMC
date: 2021-11-02
doi: 10.21203/rs.3.rs-1029803
cited_by_count: 0
techniques: Bicinchoninic Acid Protein Assay; Blocking Assay; Centrifugation; Expressing; Incubation; Isolation; Lysis; Membrane; Software; Transfection; Western Blot
bioz_score: 90
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