| Catalog No. | Size | Price (USD) |
| 11066-HNAH-1 | 1 mg | $4,440.36 |
| 11066-HNAH-5 | 5 µg | $100.72 |
| 11066-HNAH-20 | 20 µg | $367.31 |
| 11066-HNAH-100 | 100 µg | $737.59 |
| 11066-HNAH-500 | 500 µg | $1,907.67 |
General Information
| Formulation | Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 8.0 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Endotoxin | < 10 EU per mg protein. |
| Shipping | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Stability & Storage | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution | To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA. |
| Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ≥ 95 % as determined by SEC-MALS(Routinely tested). |
| Activity | 1.iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) 2. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC). The ED 50 for this effect is typically 2-10 ng/mL. 3. Labeled biotin to VEGF165 Protein, Human / Cynomolgus, Recombinant by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of VEGF165 Protein, Human / Cynomolgus, Recombinant, Biotinylated(Cat:11066-HNAH-B) bound to Avastin was 0.1 nM. 4. Anti-VEGF (Research Grade Bevaciz*mab Biosimilar) captured on Protein A chip can bind Recombinant Human, Cynomolgus VEGF165 Protein (Cat. No. 11066-HNAH) with an affinity constant of 14.9 pM as determined in an SPR assay (Biacore 8K) (Routinely tested). 5.Loaded Biotinylated Recombinant Human VEGFR1/FLT1 Protein, His & AVI Tag (Cat. No. 10136-H49H-B) on SA Biosensor, can bind Recombinant VEGF165 Protein, Human, Cynomolgus (Cat. No. 11066-HNAH) with an affinity constant of 0.506 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). |
| Protein Construction | A DNA sequence encoding the human / cynomolgus VEGF165 isoform (P15692-4) (Met1-Arg191) was expressed. Human and Cynomolgus VEGF165 sequences are identical. |
| Accession# | P15692-4 |
| Expressed Host | HEK293 Cells |
| Species | Human, Cynomolgus |
| Predicted N Terminal | Ala 27 |
| Molecule Mass | The recombinant human / cynomolgus VEGF165 consists of 165 amino acids and predicts a molecular mass of 19.2 KDa. It migrates as an approximately 22 kDa and 24 kDa band in SDS-PAGE under reducing conditions. The molecular weight of this protein is around 44.9 kDa verified by SEC-MALS(Routinely tested). |
Image / Experimental Information
| Image 1 Description | iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) |
| Image 1 Alt Text | Human FGF2 Protein 35969 |
| Image 1 URL | Source image |
| Image 2 Description | iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) |
| Image 2 Alt Text | Human, Cynomolgus VEGF-A Protein 41736 |
| Image 2 URL | Source image |
| Image 3 Description | iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) |
| Image 3 Alt Text | Human VEGFR1/FLT1 Protein 42961 |
| Image 3 URL | Source image |
| Image 4 Description | iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) |
| Image 4 Alt Text | Human, Cynomolgus VEGF-A Protein 49200 |
| Image 4 URL | Source image |
| Image 5 Description | iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) |
| Image 5 Alt Text | Human VEGF/VEGFA/VEGF165 Protein 9365 |
| Image 5 URL | Source image |
Background Information
| Full Name | vascular endothelial growth factor A |
| Description | Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor. |
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| References |
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title: Engineered human iPSC-derived dendritic cells dressed with tumor MHC complexes as a cancer vaccine.
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title: Recombinant protein targeting PD-L1 and VEGF and compositions thereof
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title: IMM2510, a novel anti-PD-L1/VEGF bispecific antibody for cancer immunotherapy
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journal: Antibody Therapeutics
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pmid: 41804385
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techniques: Activity Assay; Binding Assay; Blocking Assay; Control; Enzyme-linked Immunosorbent Assay; Flow Cytometry; Inhibition; Mlr Assay; Produced; Recombinant; Reporter Assay
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title: Gamma-synuclein drives bevacizumab resistance in colorectal cancer via VEGFR2 activation and angiogenesis.
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journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
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title: Niche Environment Remodeling Promotes Long-Term Endometrium Stromal Stem Cell Engraftment and Tissue Regeneration in Thin Endometrium.
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title: Glycosylation-enabled chemoselective growth factor engineering for biomaterial functionalization.
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title: Engineered Subcutaneous Site for Optimal Organoid Transplantation
journal: Engineering
date: 2025-10-01
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techniques: Cell Culture; Confocal Microscopy; Control; Modification; Transfection; Transplantation Assay
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title: G6PD deficiency is implicated in Circle of Willis variants in stroke patients and impairs brain vasculature in zebrafish
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journal: Journal of Cerebral Blood Flow & Metabolism
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techniques: Recombinant
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title: Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents
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journal: Nature Communications
date: 2025-08-07
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techniques: Concentration Assay; Electron Microscopy; Enzyme-linked Immunosorbent Assay; In Vitro; Transmission Assay
bioz_score: 95
title: Anti-angiogenesis enhances the tumor immunotherapeutical effect of recombinant CD80 fusion protein.
authors: Songna Wang; Litao Huang; ...; Li Ye
journal: International Journal of Biological Macromolecules
date: 2025-07-27
pmid: 40730308
doi: 10.1016/j.ijbiomac.2025.146350
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techniques: Binding Assay
bioz_score: 95
title: A costal-cartilage derived stem cell-laden prominin-1-derived peptide collagen hydrogel for angiogenesis and bone regeneration.
authors: Chenhui Cai; Rui Zuo; ...; Chao Zhang
journal: Acta Biomaterialia
date: 2025-07-10
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techniques: Concentration Assay; In Vitro
bioz_score: 95
title: Gamma-synuclein promotes Bevacizumab resistance by activating vascular endothelial growth factor receptor in colorectal cancer
authors: Caiyun liu; Lixin Wang; ...; chengchao shou
journal: Research Square
date: 2024-11-27
doi: 10.21203/rs.3.rs-5414606/v1
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techniques: Cell Culture; Isolation
bioz_score: 94
title: Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery.
authors: Zihang Pan; Qiyang Yao; ...; Kai Wang
journal: Cell Stem Cell
date: 2024-11-22
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doi: 10.1016/j.stem.2024.10.015
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techniques: Recombinant
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title: Development of bioassay platforms for biopharmaceuticals using Jurkat-CAR cells by AICD.
authors: Dianze Chen; Song Li; ...; Wenzhi Tian
journal: Journal of Pharmaceutical and Biomedical Analysis
date: 2024-08-22
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techniques: CCK-8 Assay; Proliferation Assay
bioz_score: 95
title: Humanized anti-VEGF monoclonal antibody
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date: 2024-08-13
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techniques: Adjuvant; Binding Assay; Blocking Assay; Recombinant; Sequencing
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title: Pre-Clinical Studies of a Novel Bispecific Fusion Protein Targeting C3b and VEGF in Neovascular and Nonexudative AMD Models
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journal: Ophthalmology and therapy
date: 2024-06-21
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techniques: Activity Assay; Bioassay; Blocking Assay; Concentration Assay; Construct; Expressing; Functional Assay; Hemolysis Assay; In Vitro; Incubation; Luciferase; Reporter Assay
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title: Granular Biomaterials as Bioactive Sponges for the Sequestration and Release of Signaling Molecules.
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journal: Advanced Healthcare Materials
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title: Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies.
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title: Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny
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journal: The Journal of Biological Chemistry
date: 2024-02-08
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title: Anti-PD-1/anti-VEGF natural antibody structure like heterodimeric form bispecific antibody and preparation thereof
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date: 2023-11-28
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title: Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
authors: Shuqian Zhu; Shilong Fan; ...; Feng Qian
journal: Bioengineering & Translational Medicine
date: 2023-11-01
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techniques: High Performance Liquid Chromatography; Recombinant
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title: Recombinant protein targeting PD-L1 and VEGF
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date: 2022-08-09
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title: A Silicone Oil-Free Syringe Tailored for Intravitreal Injection of Biologics
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date: 2021-12-02
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techniques: Binding Assay; Injection
bioz_score: 95
title: Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins
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date: 2021-10-07
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techniques: Binding Assay; Conjugation Assay; Negative Control; Recombinant; Sequencing; Synthesized
bioz_score: 95
title: Fisetin inhibits vascular endothelial growth factor-induced angiogenesis in retinoblastoma cells
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journal: Oncology Letters
date: 2020-08-01
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techniques: Concentration Assay; High Performance Liquid Chromatography; Inhibition; Negative Control
bioz_score: 95
title: A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis.
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journal: Oncogene
date: 2020-04-17
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techniques: Incubation; Luciferase; Recombinant; Staining
bioz_score: 95
title: An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells
authors: Takahito Ohira; Koichi Miyauchi; ...; Hiroyuki Kugoh
journal: Scientific Reports
date: 2019-11-18
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doi: 10.1038/s41598-019-53116-2
pmcid: 6861226
cited_by_count: 6
techniques: Blocking Assay; Cell Culture; Clone Assay; Enzyme-linked Immunosorbent Assay; Incubation; Labeling; Molecular Weight; Plasmid Preparation; Purification; SDS Page; Silver Staining; Staining; Western Blot
bioz_score: 95
title: Efficient Production of a Bioactive Bevacizumab Monoclonal Antibody Using the 2A Self-cleavage Peptide in Transgenic Rice Callus
authors: Lei Chen; Xiaoyu Yang; ...; Weichang Yu
journal: Frontiers in Plant Science
date: 2016-08-09
pmid: 27555853
doi: 10.3389/fpls.2016.01156
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cited_by_count: 18
techniques: Activity Assay; Binding Assay; Construct; Enzyme-linked Immunosorbent Assay; Incubation; Negative Control; Positive Control; Purification; Transgenic Assay
bioz_score: 95
title: Injectable Chemically Crosslinked Hydrogel for the Controlled Release of Bevacizumab in Vitreous: A 6-Month In Vivo Study
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date: 2015-03-10
pmid: 25774331
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cited_by_count: 95
techniques: Filtration; Purification
bioz_score: 95
