| Catalog No. | Size | Price (USD) |
| 104926-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-Alpha B Crystallin Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Alpha B Crystallin |
| Immunogen | A synthetic peptide corresponding to the center region of the Human Alpha B Crystallin |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human Alpha B Crystallin, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CMD1II Antibody; Anti-CRYA2 Antibody; Anti-CTPP2 Antibody; Anti-CTRCT16 Antibody; Anti-HEL-S-101 Antibody; Anti-HSPB5 Antibody; Anti-MFM2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CRYAB in human muscle with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Alpha B Crystallin Immunohistochemistry(IHC) 41573 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CRYAB in human muscle with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Alpha B Crystallin Immunohistochemistry(IHC) 41574 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CRYAB in human muscle with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Alpha B Crystallin Immunohistochemistry(IHC) 41575 |
| Image 3 URL | Source image |
Background Information
| Full Name | crystallin, alpha B |
| Description | Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. Mutations in alpha-B crystallin gene (CRYAB) have been described to cause congenital cataracts, dilated cardiomyopathy and myofibrillar myopathy. Mutations in the alphaB-crystallin (CRYAB) gene, encoding a small heat shock protein with chaperone function, are a rare cause of myofibrillar myopathy with autosomal-dominant inheritance, late-onset and moderate severity. Mutations in the CRYAB gene, encoding alpha-B crystallin, cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. CRYAB may be identified as a novel prognostic marker and targeting CRYAB may provide a promising strategy for NSCLC treatment. |
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