| Catalog No. | Size | Price (USD) |
| 200156-T32-50 | 50 µL | $147.96 |
| 200156-T32-100 | 100 µL | $251.64 |
| 200156-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Claudin-1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Claudin-1 |
| Immunogen | E. coli-derived Human Claudin-1/CLDN1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Claudin-1/CLDN1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CLD1 Antibody; Anti-ILVASC Antibody; Anti-SEMP1 Antibody; Anti-UNQ481/PRO944 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CLDN1 rabbit polyclonal antibody at 1:500 dilution Lane A: HepG2 Whole Cell Lysate Lane B: A549 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:23 kDa Observed band size:23 kDa |
| Image 1 Alt Text | Human Claudin-1 Western blot (WB) 23579 |
| Image 1 URL | Source image |
Background Information
| Full Name | claudin 1 |
| Description | The gene encoding claudin-1 (CLDN1) has been mapped to human chromosome 3. The claudin-1 gene (CLDN1) is a member of a family of genes that encodes proteins found in tight junctions and it has been implicated as one of several receptors for late stage binding of hepatitis C virus (HCV). Claudin-1 is a recently discovered co-receptor for hepatitis C virus (HCV) that is required for late-stage binding of the virus. Because variants in the gene that encodes claudin-1 (CLDN1) could play a role in HCV infection, the genetic variants in regulatory regions of CLDN1 may alter susceptibility to HCV infection. Claudin1 (CLDN1) plays an important role not only in the intercellular barrier function of tight junctions (TJs) but also in migration and invasiveness of cancer cells. Previous cDNA microarrays indicated that CLDN1 (claudin-1) is an important gene for ovarian cancer-initiating cell (OCIC) invasion and adhesion. Tight junction protein claudin-1 (CLDN1) is mainly involved in the intercellular barrier function of epithelial cells and is known to be dysregulated in many cancer types, including gastrointestinal cancers. CLDN1 (claudin1) is essential for intercellular junctions and has been reported to be involving in cell migration and metastasis, making it as an oncogene in various cancer types. The miR-29a may regulate tumor growth and migration by targeting CLDN1, providing promising therapeutic targets for HCC. |
-HD12AU1448-WB.png){kind=link}