| Catalog No. | Size | Price (USD) |
| 80316-T24-50 | 50 µL | $147.96 |
| 80316-T24-100 | 100 µL | $251.64 |
| 80316-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Contactin 3 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat Contactin 3 |
| Immunogen | Recombinant Rat Contactin 3 / CNTN3 protein (Catalog#80316-R08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Rat Contactin 3 / CNTN3 (Catalog#80316-R08H; Q62682; Met1-Gly1001). Contactin 3 / CNTN3 specific IgG was purified by Rat Contactin 3 / CNTN3 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BIG-1 Antibody; Anti-Cntn3 Antibody; Anti-Pang Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of rat CNTN3 in rat brain with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Rat Contactin 3/CNTN3 Immunohistochemistry(IHC) 3133 |
| Image 1 URL | Source image |
Background Information
| Full Name | contactin 3 (plasmacytoma associated) |
| Description | Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-3, also known as CNTN3 (BIG-1 in rat and PANG in mouse), is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells, amygdaloid and thalamic neurons and olfactory granule cells. In the brain, Contactin-3 is expressed in frontal lobe, occipital lobe, cerebellum and amygdala. Contactin-3 contains 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. Human Contactin-3 shares 92% aa identity with mouse Contactin-3. The exact function of Contactin-3 is unclear. Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth. |
| References |
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