Anti-CXCL5 Antibody, Rabbit Polyclonal sinobiological 203559-T32

$143.00
In stock
SKU
203559-T32
Catalog No.SizePrice (USD)
203559-T32-5050 µL$147.96
203559-T32-100100 µL$251.64
203559-T32-200200 µL$340.51

General Information

Product nameAnti-CXCL5 Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CXCL5
ImmunogenE. coli-derived Human CXCL5 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human CXCL5 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ENA-78 Antibody; Anti-ENA78 Antibody; Anti-SCYB5 Antibody

Image / Experimental Information

Image 1 DescriptionAnti-CXCL5 rabbit polyclonal antibody at 1:500 dilution Lane A: A549 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:12 kDa Observed band size:12 kDa
Image 1 Alt TextHuman CXCL5 Western blot (WB) 23109
Image 1 URLSource image

Background Information

Full Namechemokine (C-X-C motif) ligand 5
DescriptionCXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.
Related Pathways
  • IL17 signaling pathway
References
  1. Dawes JM, et al. (2011) CXCL5 Mediates UVB Irradiation-Induced Pain. Sci Transl Med. 3(90): 90ra60.
  2. O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  3. Persson T, et al. (2003) Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils. Clin Exp Allergy. 33(4):531-7.

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