| Catalog No. | Size | Price (USD) |
| 205461-T08-50 | 50 µL | $147.96 |
| 205461-T08-100 | 100 µL | $251.64 |
| 205461-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-DUSP8 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human DUSP8 |
| Immunogen | E. coli-derived Human DUSP8 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human DUSP8 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-C11orf81 Antibody; Anti-FLJ42958 Antibody; Anti-HB5 Antibody; Anti-HVH-5 Antibody; Anti-HVH8 Antibody; Anti-VH5 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human DUSP8 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human DUSP8 Immunohistochemistry(IHC) 25823 |
| Image 1 URL | Source image |
Background Information
| Description | Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases (PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and phosphor-tyrosine on mitogen-activated protein kinases (MAPKs), and hence are also referred to as MAPK phosphatases (MKPs). Homologue of Vaccinia virus H1 phosphatase gene clone 5 (HVH-5), also known as DUSP8, is a unique member of the DUSPs family of phosphatases. DUSP8 plays an important role in phosphorylation-mediated signal transduction of MAPK signaling ranging from cell oxidative stress response, cell apoptosis and various human diseases. DUSP8 regulates cell proliferation and collagen synthesis in cardiac fibroblasts through p38 and c-Jun N-terminal kinase (JNK)/stress-activated kinase (SAPK) signalling. |
| References |
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