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Anti-EGFR Antibody (Biotin), Mouse Monoclonal sinobiological 10001-MM08T-B

Anti-EGFR Antibody (Biotin), Mouse Monoclonal sinobiological 10001-MM08T-B

Name: Anti-EGFR Antibody (Biotin), Mouse Monoclonal sinobiological 10001-MM08T-B
SKU: 10001-MM08T-B
Price: 357 USD
Availability: InStock

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$357.00

In stock

SKU

10001-MM08T-B

Catalog No.	Size	Price (USD)
10001-MM08T-B-100	100 µg	$370.28

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Product introduction

General Information

Product name	Anti-EGFR Antibody (Biotin), Mouse Monoclonal
Validated applications	ELISA (FAQ Protocol)
Species reactivity	Reacts with: Human
Specificity	Human EGFR
Immunogen	Recombinant Human EGFR / HER1 / ErbB1 protein (Catalog#10001-H08H)
Preparation	This product is a recombinant monoclonal antibody expressed from HEK293 cells and then biotinylated.
Source	Monoclonal Mouse IgG1 Clone #08
Purification	Protein A
Formulation	0.2 μm filtered solution in PBS
Conjugate	Biotin
Form	Liquid
Shipping	This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-ERRP Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody

Background Information

Full Name	epidermal growth factor receptor
Description	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Research Areas	Cancer Drug Targets Receptor Tyrosine Kinases (RTKs)
Related Pathways	EGFR Signaling Pathway Jak-Stat Signaling Pathway
Tags	Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
References	Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25. Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48. Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.