| Catalog No. | Size | Price (USD) |
| 204388-T02-50 | 50 µL | $147.96 |
| 204388-T02-100 | 100 µL | $251.64 |
| 204388-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ERCC5 Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ERCC5 |
| Immunogen | E. coli-derived Human ERCC5 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ERCC5 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-COFS3 Antibody; Anti-ERCC5-201 Antibody; Anti-ERCM2 Antibody; Anti-UVDR Antibody; Anti-XPG Antibody; Anti-XPGC Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of ERCC5 in U251MG cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human ERCC5 polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus. |
| Image 1 Alt Text | Human ERCC5 Immunofluorescence(IF) 24347 |
| Image 1 URL | Source image |
Background Information
| Description | Excision repair cross-complementation group 5 (ERCC5) gene plays an important role in nucleotide excision repair, and dysregulation of ERCC5 is associated with increased lung cancer risk. Excision repair cross-complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus contribute to cancer risk. The excision repair cross-complementation group 5 (ERCC5) gene is a central component of NER. Ectopic expression of ERCC5 has been linked to different types of cancers, including hepatocellular carcinoma (HCC). Single nucleotide polymorphism in ERCC5 was responsible for different cancers. |
| References |
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