Anti-Ferritin heavy chain 1/FTH1 Antibody, Mouse Monoclonal sinobiological 13217-MM02T

$86.00
In stock
SKU
13217-MM02T
Catalog No.SizePrice (USD)
13217-MM02T-2020 µL$88.87
13217-MM02T-5050 µL$133.15
13217-MM02T-100100 µL$251.64
13217-MM02T-200200 µL$340.51

General Information

Product nameAnti-Ferritin heavy chain 1/FTH1 Antibody, Mouse Monoclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman Ferritin heavy chain 1/FTH1
ImmunogenRecombinant Human Ferritin heavy chain 1 / FTH1 Protein (Catalog#13217-HNAE)
PreparationThis product is a recombinant monoclonal antibody expressed from HEK293 cells.
SourceMonoclonal Mouse IgG1 Clone #02
PurificationProtein A
Formulation50mM Hepes, 100mM NaCl. 10% Trehalose, 0.02% Tween80, pH7.5.
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-FHC Antibody; Anti-FTH Antibody; Anti-FTHL6 Antibody; Anti-HFE5 Antibody; Anti-NBIA9 Antibody; Anti-OK/SW-cl.84 Antibody; Anti-PIG15 Antibody; Anti-PLIF Antibody

Background Information

Full Nameferritin, heavy polypeptide 1
DescriptionFTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. FTH1 gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. FTH1 stores iron in a soluble, non-toxic, readily available form. It is important for iron homeostasis. It has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. It also plays a role in delivery of iron to cells. FTH1 mediates iron uptake in capsule cells of the developing kidney.
References
  1. Hentze MW, et al. (1986) Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. Proc Natl Acad Sci. 83(19):7226-30.
  2. Rual, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature. 437(7062):1173-8.
  3. Stelzl, et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122(6):957-968.

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