Recombinant Human GGCT protein (Catalog#14366-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human GGCT (rh GGCT; Catalog#14366-H07E; O75223-1; Met1-Leu188). GGCT specific IgG was purified by Human GGCT affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in glutathione homeostasis. GGCT also induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Pseudogenes of GGCT gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
References
Wagner SA. et al., 2011, Mol Cell Proteomics. 10 (10): M111.013284.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
Amano T. et al., 2012, J Histochem Cytochem. 60 (1): 76-86.