Produced in rabbits immunized with E. coli-derived Human GPRASP1 fragment, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
GPRASP1 gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). GPRASP1 plays a major role in the postendocytic sorting process.
References
Monestier O, et al. (2012) Ubiquitous gasp1 overexpression in mice leads mainly to a hypermuscular phenotype. BMC Genomics 13 541.
Martini L, et al. (2007) Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the g-protein-coupled receptor-associated sorting protein gasp1. Faseb j 21 (3): 802-811.
Lee YS, et al. (2015) Roles of gasp-1 and gdf-11 in dental and craniofacial development. J Oral Med Pain 40 (3): 110-114.