Anti-GPRASP1 Antibody, Rabbit Polyclonal sinobiological 205358-T10

$143.00
In stock
SKU
205358-T10
Catalog No.SizePrice (USD)
205358-T10-5050 µL$147.96
205358-T10-100100 µL$251.64
205358-T10-200200 µL$355.32

General Information

Product nameAnti-GPRASP1 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol), ICC/IF (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman GPRASP1
ImmunogenE. coli-derived Human GPRASP1 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human GPRASP1 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-GASP Antibody; Anti-GASP-1 Antibody; Anti-GASP1 Antibody; Anti-KIAA0443 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human GPRASP1 in human brain with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman GPRASP1 Immunohistochemistry(IHC) 25787
Image 1 URLSource image
Image 2 DescriptionImmunochemical staining of human GPRASP1 in human brain with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Image 2 Alt TextHuman GPRASP1 Immunofluorescence(IF) 25788
Image 2 URLSource image

Background Information

DescriptionGPRASP1 gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). GPRASP1 plays a major role in the postendocytic sorting process.
References
  1. Monestier O, et al. (2012) Ubiquitous gasp1 overexpression in mice leads mainly to a hypermuscular phenotype. BMC Genomics 13 541.
  2. Martini L, et al. (2007) Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the g-protein-coupled receptor-associated sorting protein gasp1. Faseb j 21 (3): 802-811.
  3. Lee YS, et al. (2015) Roles of gasp-1 and gdf-11 in dental and craniofacial development. J Oral Med Pain 40 (3): 110-114.

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