| Catalog No. | Size | Price (USD) |
| 40104-RP01-20 | 20 µL | $88.87 |
| 40104-RP01-100 | 100 µL | $251.64 |
| 40104-RP01-200 | 200 µL | $370.28 |
General Information
| Product name | Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin / HA Antibody, Rabbit PAb |
| Validated applications | ELISA (FAQ Protocol) |
| Application notes | IHC, FCM, IF, IP et al. applications haven't been validated. (Antibody's applications haven't been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin / HA |
| Immunogen | Recombinant Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin / HA Protein (Catalog#40104-V08B) |
| Preparation | Produced in rabbits immunized with purified, recombinant Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin / HA (Catalog#40104-V08B; Met1-Val524). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Background Information
| Full Name | Hemagglutinin |
| Description | The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity. |
| References |
|
title: HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian influenza virus.
authors: Yi-Qun Chen; Guan-Ming Su; ...; Wen-Bao Qi
journal: Veterinary Microbiology
date: 2023-10-01
pmid: 37683421
doi: 10.1016/j.vetmic.2023.109852
cited_by_count: 1
techniques: Imaging; Negative Control; Stripping Membranes; Western Blot
bioz_score: 95
title: Combined insertion of basic and non-basic amino acids at hemagglutinin cleavage site of highly pathogenic H7N9 virus promotes replication and pathogenicity in chickens and mice
authors: Aobaixue Zhou; Jiahao Zhang; ...; Wenbao Qi
journal: Virologica Sinica
date: 2022-01-13
pmid: 35234617
doi: 10.1016/j.virs.2022.01.001
pmcid: 8922421
cited_by_count: 6
techniques: Imaging; Stripping Membranes; Western Blot
bioz_score: 95
title: Development of an Influenza A Master Virus for Generating High-Growth Reassortants for A/Anhui/1/2013(H7N9) Vaccine Production in Qualified MDCK Cells
authors: Yasushi Suzuki; Takato Odagiri; ...; Toru Takimoto
journal: PLoS ONE
date: 2016-07-25
pmid: 27454606
doi: 10.1371/journal.pone.0160040
pmcid: 4959774
cited_by_count: 10
techniques: Electrophoresis; Purification; Recombinant; SDS Page; Western Blot
bioz_score: 95
