| Catalog No. | Size | Price (USD) |
| 206774-T08-50 | 50 µL | $147.96 |
| 206774-T08-100 | 100 µL | $251.64 |
| 206774-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Grin2b Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Grin2b |
| Immunogen | E. coli-derived Human Grin2b fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Grin2b fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-DEE27 Antibody; Anti-EIEE27 Antibody; Anti-GluN2B Antibody; Anti-GRIN2B Antibody; Anti-hNR3 Antibody; Anti-MRD6 Antibody; Anti-NMDAR2B Antibody; Anti-NR2B Antibody; Anti-NR3 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human Grin2b in cynomolgus cerebellum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Grin2b Immunohistochemistry(IHC) 26574 |
| Image 1 URL | Source image |
Background Information
| Description | N-methyl-D-aspartate receptors (NMDARs) are a family of ionotropic glutamate receptors that mediate a slow, Ca permeable component of excitatory synaptic transmission in the central nervous system (CNS). NMDARs are a tetrameric assembly of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. The GluN1 subunit is expressed throughout the CNS, whereas the four subtypes of GluN2 (A-D) subunits have differential temporal and spatial expression patterns. The GluN2B subunit encoded by GRIN2B is highly expressed prenatally, and its expression level starts to decline after birth in most brain regions. The early expression of this NMDAR subunit suggests it may play an important role in brain development, circuit formation, and perhaps cellular migration and differentiation, as well as synaptic plasticity. GluN2B expression dominates during rapid cortical synaptogenesis in late embryogenesis and early postnatal development. |
| References |
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