| Catalog No. | Size | Price (USD) |
| 11048-RM07-20 | 20 µL | $118.49 |
| 11048-RM07-50 | 50 µL | $222.17 |
| 11048-RM07-100 | 100 µL | $370.28 |
General Information
| Product name | Influenza A H5N1 (Avian Flu) Hemagglutinin / HA Antibody, Rabbit MAb |
| Validated applications | ELISA (FAQ Protocol) |
| Application notes | IHC, FCM, IF, IP et al. applications haven't been validated. (Antibody's applications haven't been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | H5N1 (A/Anhui/1/2005) HA H5N1 (A/Anhui/1/2005) HA2 Sub-unit Has cross-reactivity in ELISA with H5N1 (A/Anhui/1/2005) HA Protein (Cat# 11048-V08H1) H5N1 (A/dairy cow/Texas/24-008749-002) HA Protein (Cat# 41036-V08H) H5N1 (A/turkey/Turkey/1/2005) HA H5N1 (A/Indonesia/5/2005) HA H5N1 (A/Viet Nam/1203/2004) HA H5N1 (A/chicken/India/NIV33487/2006) HA H5N1 (A/goose/Guiyang/337/2006) HA H5N1 (A/Hong Kong/483/97) HA H5N1 (A/Cambodia/R0405050/2007) HA H5N1 (A/Egypt/N05056/2009) HA H5N1 (A/duck/Hunan/795/2002) HA H5N1 (A/Egypt/2321-NAMRU3/2007) HA H5N3 (A/duck/Hokkaido/167/2007) HA H5N8 (A/duck/NY/191255-59/2002) HA H5N1 (A/whooper swan/mongolia/244/2005) HA H5N1 (A/bar-headed goose/Qinghai/14/2008) HA H5N1 (A/Common magpie/Hong Kong/2256/2006) HA No cross-reactivity in ELISA with H1N1 (A/California/04/2009) HA H1N1 (A/California/04/2009) HA1 Sub-unit H1N1 (A/Brisbane/59/2007) HA H1N1 (A/Brevig Mission/1/1918) HA H3N2 (A/Brisbane/10/2007) HA Influenza B (B/Florida/4/2006) HA |
| Immunogen | Recombinant H5N1 HA protein (Catalog#11048-V08H1) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Influenza A virus H5N1 (Avian Flu) Hemagglutinin extracellular domain. |
| Source | Monoclonal Rabbit IgG Clone #82 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Background Information
| Full Name | Hemagglutinin |
| Description | The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity. |
| References |
|
title: Recombinant parainfluenza virus 5 expressing clade 2.3.4.4b H5 hemagglutinin protein confers broad protection against H5Ny influenza viruses.
authors: Han Li; Haoran Sun; ...; Honglei Sun
journal: Journal of virology
date: 2024-03-20
pmid: 38305155
cited_by_count: 4
techniques: Blocking Assay; Fluorescence; Imaging; Incubation; Infection; Labeling; Lysis; Membrane; Microscopy; Western Blot
bioz_score: 95
title: Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
authors: Dongming Zhao; Libin Liang; ...; Hualan Chen
journal: Journal of virology
date: 2017-04-01
doi: 10.1128/jvi.02215-16
cited_by_count: 40
techniques: Fluorescence; Immunofluorescence; Infection; Staining; Virus
bioz_score: 95
title: Neu5Acα2,6Gal and Neu5Acα2,3Gal receptor specificities on influenza viruses determined by a waveguide-mode sensor.
authors: S C B Gopinath; K Awazu; ...; K Shimizu
journal: Acta Biomaterialia
date: 2013-06-11
pmid: 23022889
doi: 10.1016/j.actbio.2012.09.027
cited_by_count: 31
techniques: Recombinant
bioz_score: 95
