| Catalog No. | Size | Price (USD) |
| 205059-T08-50 | 50 µL | $147.96 |
| 205059-T08-100 | 100 µL | $251.64 |
| 205059-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-HTR3B Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human HTR3B |
| Immunogen | E. coli-derived Human HTR3B fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human HTR3B fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-5-HT3B Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human HTR3B in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human HTR3B Immunohistochemistry(IHC) 25629 |
| Image 1 URL | Source image |
Background Information
| Description | The 5-HT3 receptor is a ligand-gated ion channel that has five subunits, 5HT3A-E, coded by the genes HTR3A-E. The HTR3A-B genes are positioned on chromosome 11q23.1—q23.2 and contain 7 and 9 exons, respectively. The HTR3C-E genes are positioned on chromosome 3q27.1. The 5-HT3A and 5-HT3B subunits are approximately 44% identical in amino acid sequence and are encoded by two genes (HTR3A and HTR3B). 5-HT3A and 5-HT3B are expressed in several brain regions, including the amygdala, caudate, and hippocampus. The 5-HT3A subunit forms functional homomeric 5-HT3A receptors, while the other subunits cannot assembly into functional receptors alone. Instead they form heteromeric receptors with the 5-HT3A receptor. |
| References |
|
title: Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer.
authors: Tianlong Ling; Zhanghan Dai; ...; Jianjun Chen
journal: Cancer letters
date: 2024-09-02
pmid: 39097134
doi: 10.1016/j.canlet.2024.217150
cited_by_count: 10
techniques: Activity Assay; Blocking Assay; Immunohistochemical staining; Immunohistochemistry; Incubation; Isolation; Labeling; Staining; Sterility
bioz_score: 92
-HD12DE0757-100-human-kidney-IHC-P.png){kind=link}