| Catalog No. | Size | Price (USD) |
| 11294-R101-50 | 50 µL | $177.58 |
| 11294-R101-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human AKR1B1 |
| Immunogen | Recombinant Human AKR1B1 Protein (Catalog#11294-H07E) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human AKR1B1 (rh AKR1B1; Catalog#11294-H07E; P15121; Met1-Phe316). |
| Source | Monoclonal Rabbit IgG Clone #101 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ADR Antibody; Anti-ALDR1 Antibody; Anti-ALR2 Antibody; Anti-AR Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Human AKR1B1 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human AKR1B1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Human AKR1B1 Flow Cytometry (FC) 5352 |
| Image 1 URL | Source image |
Background Information
| Full Name | aldo-keto reductase family 1, member B1 (aldose reductase) |
| Description | Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily. |
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