| Catalog No. | Size | Price (USD) |
| 10549-R128-50 | 50 µL | $177.58 |
| 10549-R128-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Aminoacylase 1 Antibody, Rabbit Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Aminoacylase 1 |
| Immunogen | Recombinant Human ACY1 / Aminoacylase-1 protein (Catalog#10549-H08B) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human ACY1 / Aminoacylase-1 (rh ACY1 / Aminoacylase-1; Catalog#10549-H08B; NP_000657.1; Met1-Ser408). |
| Source | Monoclonal Rabbit IgG Clone #128 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ACY-1 Antibody; Anti-ACY1D Antibody; Anti-HEL-S-5 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ACY1 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. |
| Image 1 Alt Text | Human Aminoacylase-1/ACY1 Immunohistochemistry(IHC) 4749 |
| Image 1 URL | Source image |
Background Information
| Full Name | aminoacylase 1 |
| Description | Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine. |
| References |
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