| Catalog No. | Size | Price (USD) |
| 10448-RP01-100 | 100 µL | $147.96 |
| 10448-RP01-200 | 200 µL | $251.64 |
| 10448-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-Annexin V/ANXA5 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Annexin V/ANXA5 |
| Immunogen | Recombinant Human ANXA5 / Annexin Ⅴ / Annexin A5 protein (Catalog#10448-HNAE) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ANXA5 / Annexin Ⅴ / Annexin A5 (rh ANXA5 / Annexin Ⅴ / Annexin A5; Catalog#10448-HNAE; P08758; Met1-Asp320). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ANX5 Antibody; Anti-CPB-I Antibody; Anti-ENX2 Antibody; Anti-HEL-S-7 Antibody; Anti-PAP-I Antibody; Anti-PP4 Antibody; Anti-RPRGL3 Antibody; Anti-VAC-alph Antibody
Background Information
| Full Name | annexin A5 |
| Description | The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis. |
| References |
|
