Anti-CD160 Antibody, Rabbit Polyclonal sinobiological 12191-RP02

$143.00
In stock
SKU
12191-RP02
Catalog No.SizePrice (USD)
12191-RP02-5050 µL$147.96
12191-RP02-100100 µL$251.64
12191-RP02-200200 µL$355.32

General Information

Product nameAnti-CD160 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD160
ImmunogenRecombinant Human CD160 protein (Catalog#12191-H08H)
PreparationProduced in rabbits immunized with purified, recombinant Human CD160 (rh CD160; Catalog#12191-H08H; NP_008984.1; Met 1-Leu 158). CD160 specific IgG was purified by Human CD160 affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-BY55 Antibody; Anti-NK1 Antibody; Anti-NK28 Antibody

Background Information

Full NameCD160 molecule
DescriptionCD16 antigen, also known as Natural killer cell receptor BY55 and CD16, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD16 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD16 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD16 is expressed in spleen, peripheral blood, and small intestine. Expression of CD16 is restricted to functional NK and T cytotoxic lymphocytes. CD16 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD16+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD16+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD16 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
Research Areas
  • Cancer Drug Targets
Tags
  • Cancer Immunotherapy
  • Co-inhibitory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: Antibodies
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: FCM Antibodies
  • Immune Checkpoint Detection: IHC Antibodies
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
References
  1. Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
  2. Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
  3. Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
  4. Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.

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