Anti-CD19 Antibody, Mouse Monoclonal sinobiological 11880-MM02

$1,329.00
In stock
SKU
11880-MM02
Catalog No.SizePrice (USD)
11880-MM02-11 mL$1,377.43
11880-MM02-2020 µL$88.87
11880-MM02-5050 µL$147.96
11880-MM02-100100 µL$251.64
11880-MM02-200200 µL$355.32

General Information

Product nameAnti-CD19 Antibody, Mouse Monoclonal
Validated applicationsELISA(Cap) (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD19
ImmunogenRecombinant Human CD19 / B4 / CVID3 Protein (Catalog#11880-H08H)
PreparationThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD19 / B4 / CVID3 (rh CD19 / B4 / CVID3; Catalog#11880-H08H; P15391-1; Met1-Lys291). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
SourceMonoclonal Mouse IgG1 Clone #02
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-B4 Antibody; Anti-CVID3 Antibody

Background Information

Full NameCD19 molecule
DescriptionThe cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in the threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell co-receptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.
Research Areas
  • Cancer Drug Targets
Related Pathways
  • B Cell Receptor Signaling Pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  4. Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.

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