| Catalog No. | Size | Price (USD) |
| 10261-R176-50 | 50 µL | $177.58 |
| 10261-R176-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-CD23 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD23 |
| Immunogen | Recombinant Human CD23 / FCER2 protein (Catalog#10261-H07H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD23 / FCER2 (rh CD23 / FCER2; Catalog#10261-H07H; P06734-1; Asp48-Ser321). |
| Source | Monoclonal Rabbit IgG Clone #176 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BLAST-2 Antibody; Anti-CD23 Antibody; Anti-CD23A Antibody; Anti-CLEC4J Antibody; Anti-FCE2 Antibody; Anti-FcepsilonRII Antibody; Anti-FCErII Antibody; Anti-IGEBF Antibody
Background Information
| Full Name | Fc fragment of IgE receptor II |
| Description | Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor). |
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