Anti-CD28 Antibody, Rabbit Polyclonal sinobiological 11524-RP01

$143.00
In stock
SKU
11524-RP01
Catalog No.SizePrice (USD)
11524-RP01-100100 µL$147.96
11524-RP01-200200 µL$251.64
11524-RP01-400400 µL$355.32

General Information

Product nameAnti-CD28 Antibody, Rabbit Polyclonal
Validated applicationsELISA (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD28
ImmunogenRecombinant Human CD28 protein (Catalog#11524-H08H)
PreparationProduced in rabbits immunized with purified, recombinant Human CD28 (rh CD28; Catalog#11524-H08H; P10747-1; Met 1-Pro 152). Total IgG was purified by Protein A affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A
Formulation0.2 μm filtered solution in PBS
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-Tp44 Antibody

Background Information

Full NameCD28 molecule
DescriptionCD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Research Areas
  • ITIM/ITAM Immunoreceptors and Related Molecules
  • Cancer Drug Targets
Related Pathways
  • T Cell Receptor Signaling Pathway
Tags
  • Cancer Immunotherapy
  • Co-stimulatory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: Antibodies
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: FCM Antibodies
  • Immune Checkpoint Detection: IHC Antibodies
  • Immune Checkpoint Detection: WB Antibodies
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
References
  1. Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
  2. Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
  3. Bjrgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.

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