Recombinant Human CD81 / TAPA1 Protein (Catalog#14244-HNCH)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD81 / TAPA1 (rh CD81 / TAPA1; Catalog#14244-HNCH; NP_004347.1; Phe113-Lys201). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
CD81, also known as TAPA-1, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via the B cell receptor by bridging Ag specific recognition and CD21-mediated complement recognition.
References
Petracca R. et al., 2000, J Virol. 74 (10): 4824-30.
Bartosch B. et al., 2003, The Journal of Biological Chemistry. 278 (43): 41624-30.
Clark KL. et al., 2001, Journal of Immunology. 167 (9): 5115-21.