Anti-COCH Antibody, Rabbit Polyclonal sinobiological 11368-T16
$243.00
In stock
SKU
11368-T16
| Catalog No. | Size | Price (USD) |
| 11368-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-COCH Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human COCH |
| Immunogen | Recombinant Human COCH Protein (Catalog#11368-H07H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human COCH (rh COCH; Catalog#11368-H07H; NP_001128530.1; Glu25-Gln550). COCH specific IgG was purified by Human COCH affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-COCH-5B2 Antibody; Anti-COCH5B2 Antibody; Anti-DFNA9 Antibody; Anti-DFNB110 Antibody; Anti-UNQ257/PRO294 Antibody
Background Information
| Full Name | cochlin |
| Description | Cochlin, also known as COCH-5B2 and COCH, is a secreted protein that contains one LCCL domain and two VWFA domains. It is an abundant inner ear protein expressed as multiple isoforms. Its function is also unknown, but it is suspected to be an extracellular matrix component. Cochlin and type II collagen are major constituents of the inner ear extracellular matrix, and Cochlin constitutes 70% of non-collagenous protein in the inner ear, the cochlin isoforms can be classified into three subgroups, p63s, p44s and p40s. The expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, deafness autosomal dominant type 9 (DFNA9). The co-localization of cochlin and type II collagen in the fibrillar substance in the subepithelial area indicate that cochlin may play a role in the structural homeostasis of the vestibule acting in concert with the fibrillar type II collagen bundles. Defects in COCH may contribute to Meniere disease which is an autosomal dominant disorder characterized by hearing loss associated with episodic vertigo. |
| References |
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