| Catalog No. | Size | Price (USD) |
| 10980-T24-20 | 20 µL | $88.87 |
| 10980-T24-50 | 50 µL | $147.96 |
| 10980-T24-100 | 100 µL | $251.64 |
| 10980-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CD8 alpha Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human, Cynomolgus |
| Specificity | Human, Cynomolgus |
| Immunogen | Recombinant Human CD8/CD8 alpha/Leu-2 Protein (Catalog#10980-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CD8/CD8 alpha/Leu-2 (rh CD8/CD8 alpha/Leu-2; Catalog#10980-H08H; NP_001759.3; Met1-Asp182). CD8/CD8 alpha/Leu-2 specific IgG was purified by Human CD8/CD8 alpha/Leu-2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD8 Antibody; Anti-CD8alpha Antibody; Anti-IMD116 Antibody; Anti-Leu2 Antibody; Anti-MAL Antibody; Anti-p32 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining CD8A in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CD8/CD8 alpha/Leu-2 Immunohistochemistry(IHC) 18305 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining CD8A in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CD8 alpha Immunohistochemistry(IHC) 21217 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining CD8A in human lymph node with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human CD8 alpha Immunohistochemistry(IHC) 21239 |
| Image 3 URL | Source image |
Background Information
| Full Name | CD8a molecule |
| Description | T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
title: CD4+ and CD8+ T-cells are not the main driver of Lassa fever pathogenesis in macaques.
authors: Jérémie Prévost; Nikesh Tailor; ...; David Safronetz
journal: JCI insight
date: 2025-09-25
pmid: 40996813
doi: 10.1172/jci.insight.199235
cited_by_count: 0
bioz_score: 94
title: TCR T cells overexpressing c-Jun have better functionality with improved tumor infiltration and persistence in hepatocellular carcinoma.
authors: Mohamed S Hussein; Qi Li; ...; Yukai He
journal: Frontiers in Immunology
date: 2023-05-24
pmid: 37215108
doi: 10.3389/fimmu.2023.1114770
cited_by_count: 14
techniques: Immunohistochemistry; Staining
bioz_score: 93
title: Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques
authors: Kim J. Hasenkrug; Friederike Feldmann; ...; Maria Gloria Dominguez Bello
journal: mBio
date: 2021-07-27
pmid: 34311582
doi: 10.1128/mBio.01503-21
pmcid: 8406331
cited_by_count: 33
techniques: Flow Cytometry; Immunohistochemical staining; Immunohistochemistry; Infection; Staining
bioz_score: 93
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