| Catalog No. | Size | Price (USD) |
| 100310-MM02-50 | 50 µL | $147.96 |
| 100310-MM02-100 | 100 µL | $251.64 |
| 100310-MM02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cytokeratin 7/KRT7 Antibody, Mouse Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cytokeratin 7/KRT7 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human KRT7 / Cytokeratin-7 |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human KRT7 / Cytokeratin-7. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG3 Clone #02 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.1% BSA, pH 7.0 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CK-7 Antibody; Anti-CK7 Antibody; Anti-K2C7 Antibody; Anti-K7 Antibody; Anti-SCL Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human KRT7 in human breast carcinoma with mouse monoclonal antibody (1:50, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human KRT7 / Cytokeratin-7 Immunohistochemistry(IHC) 14836 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human KRT7 in human breast carcinoma with mouse monoclonal antibody (1:50, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human KRT7 / Cytokeratin-7 Immunohistochemistry(IHC) 14837 |
| Image 2 URL | Source image |
Background Information
| Full Name | keratin 7, type II |
| Description | KRT7 (Keratin 7) is a Protein Coding gene. The protein encoded by this gene is a member of the keratin gene family. One AS, designated Homo sapiens keratin 7 (KRT7-AS), was selected due to its marked upregulation and concordant expression with its cognate sense counterpart, KRT7, in GC tissues and cell lines. KRT7-AS formed an RNA-RNA hybrid with KRT7 and controlled KRT7 expression at both the mRNA and the post-transcriptional levels. Moreover, forced overexpression of the KRT7-overlapping region (OL) of KRT7-AS (but not its non-KRT7-OL portions) increased keratin 7 protein levels in cells. Finally, forced overexpression of full-length KRT7-AS or OL KRT7-AS (but not its non-KRT7-OL regions) promoted GC cell proliferation and migration. |
