| Catalog No. | Size | Price (USD) |
| 10694-MM06-A-25 | 25 Tests | $133.30 |
| 10694-MM06-A-100 | 100 Tests | $414.71 |
General Information
| Product name | Anti-EpCAM/TROP1 Antibody (APC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human EpCAM/TROP1 |
| Immunogen | Recombinant Human EpCAM / TROP-1 / TACSTD1 protein (Catalog#10694-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP-1 / TACSTD1 (rh EpCAM / TROP-1 / TACSTD1; Catalog#10694-H08H; NP_002345.1; Met1-Lys265) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Mouse IgG1 Clone #06 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-17-1A Antibody; Anti-323/A3 Antibody; Anti-Ber-Ep4 Antibody; Anti-BerEp4 Antibody; Anti-CD326 Antibody; Anti-CO-17A Antibody; Anti-DIAR5 Antibody; Anti-EGP-2 Antibody; Anti-EGP314 Antibody; Anti-EGP34 Antibody; Anti-EGP40 Antibody; Anti-Ep-CAM Antibody; Anti-EPCAM Antibody; Anti-ESA Antibody; Anti-GA733-2 Antibody; Anti-HEA125 Antibody; Anti-HNPCC8 Antibody; Anti-KS1/4 Antibody; Anti-KSA Antibody; Anti-Ly74 Antibody; Anti-LYNCH8 Antibody; Anti-M1S2 Antibody; Anti-M4S1 Antibody; Anti-MH99 Antibody; Anti-MIC18 Antibody; Anti-MK-1 Antibody; Anti-MOC-31 Antibody; Anti-MOC31 Antibody; Anti-TACST-1 Antibody; Anti-TACSTD1 Antibody; Anti-TROP1 Antibody
Image / Experimental Information
| Image 1 Description | Profile of anti-EpCAM (CD326) reactivity on SKBR3 cells analyzed by flow cytometry. |
| Image 1 Alt Text | Human EpCAM/TROP-1/TACSTD1 Flow Cytometry (FC) 2598 |
| Image 1 URL | Source image |
Background Information
| Full Name | epithelial cell adhesion molecule |
| Description | Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway. |
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