| Catalog No. | Size | Price (USD) |
| 10714-R305-50 | 50 µL | $177.58 |
| 10714-R305-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-Factor H Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Factor H |
| Immunogen | Recombinant Human Complement Factor H / CFH protein (Catalog#10714-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human Complement Factor H / CFH (rh Complement Factor H / CFH; Catalog#10714-H08H; NP_000177.2; Ser 860-Arg 1231). |
| Source | Monoclonal Rabbit IgG Clone #305 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AHUS1 Antibody; Anti-AMBP1 Antibody; Anti-ARMD4 Antibody; Anti-ARMS1 Antibody; Anti-CFHL3 Antibody; Anti-FH Antibody; Anti-FHL1 Antibody; Anti-HF Antibody; Anti-HF1 Antibody; Anti-HF2 Antibody; Anti-HUS Antibody
Background Information
| Full Name | complement factor H |
| Description | Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death. Factor H protects host cells from injury resulting from unrestrained complement activation. CFH regulates complement activation on self cells by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3 convertase, C3bBb. CFH protects self cells from complement activation but not bacteria/viruses. Due to the central role that CFH plays in the regulation of complement, there are many clinical implications arrising from aberrant CFH activity. Mutations in the Factor H gene are associated with severe and diverse diseases including the rare renal disorders hemolytic uremic syndrome (HUS) and membranoproliferative glomerulonephritis (MPGN) also termed dense deposit disease (DDD), membranoproliferative glomuleronephritis type II or dense deposit disease, as well as the more frequent retinal disease age related macular degeneration (AMD). In addition to its complement regulatory activities, factor H has multiple physiological activities and 1) acts as an extracellular matrix component, 2) binds to cellular receptors of the integrin type, and 3) interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. |
| Related Pathways |
|
| References |
|
