| Catalog No. | Size | Price (USD) |
| 11389-R017-50 | 50 µL | $177.58 |
| 11389-R017-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-FLRT1 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FLRT1 No cross-reactivity in ELISA with Human FLRT3 Human FLRT2 |
| Immunogen | Recombinant Human FLRT1 protein (Catalog#11389-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human FLRT1 (rh FLRT1; Catalog#11389-H08H; Q9NZU1-1; Met1-Pro524). |
| Source | Monoclonal Rabbit IgG Clone #017 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-MGC21624 Antibody; Anti-SPG68 Antibody; Anti-UNQ752/PRO1483 Antibody
Background Information
| Full Name | fibronectin leucine rich transmembrane protein 1 |
| Description | The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an 'in vivo' role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1. |
| References |
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