| Catalog No. | Size | Price (USD) |
| 10974-RP01-100 | 100 µL | $147.96 |
| 10974-RP01-200 | 200 µL | $251.64 |
| 10974-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-gp130/IL6ST Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human gp130/IL6ST |
| Immunogen | Recombinant Human gp130 / CD130 / IL6ST Protein (Catalog#10974-HCCH) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human gp130 / CD130 / IL6ST (rh gp130 / CD130 / IL6ST; Catalog#10974-HCCH; NP_002175.2; Met1-Ile618). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD130 Antibody; Anti-CDW130 Antibody; Anti-GP130 Antibody; Anti-HIES4 Antibody; Anti-HIES4A Antibody; Anti-HIES4B Antibody; Anti-IL-6RB Antibody; Anti-IMD94 Antibody; Anti-sGP130 Antibody; Anti-STWS2 Antibody
Background Information
| Full Name | interleukin 6 signal transducer |
| Description | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
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