| Catalog No. | Size | Price (USD) |
| 10201-MHA24-200 | 200 µg | $296.22 |
| 10201-MHA24-500 | 500 µg | $444.33 |
General Information
| Product name | HER3 / ErbB3 Neutralizing Antibody |
| Validated applications | Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human HER3/ERBB3 No cross-reactivity in ELISA with Mouse ErbB3 (Catalog # 51003-M08H) Rat ErbB3 (Catalog # 80111-R08H) |
| Immunogen | Recombinant Human HER3 / ErbB3 protein (Catalog#10201-H08H) |
| Preparation | It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Human HER3 / ErbB3. The antibody was produced using recombinant antibody technology. |
| Source | Monoclonal mouse (varialbe region) / human (kappa / IgG1 constant) chimeric antibody Clone #mhA24 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0 |
| Conjugate | Unconjugated |
| Endotoxin | Please contact us for more information. |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-c-erbB-3 Antibody; Anti-c-erbB3 Antibody; Anti-ErbB-3 Antibody; Anti-erbB3-S Antibody; Anti-FERLK Antibody; Anti-HER3 Antibody; Anti-LCCS2 Antibody; Anti-MDA-BF-1 Antibody; Anti-p180-ErbB3 Antibody; Anti-p45-sErbB3 Antibody; Anti-p85-sErbB3 Antibody; Anti-VSCN1 Antibody
Image / Experimental Information
| Image 1 Description | Cell Proliferation Induced by NRG1-β1/HRG1-β1 was Neutralized by Human ErbB3/Her3 Antibody. Recombinant Human NRG1-1β1/HRG1-1β1 stimulates proliferation in the MCF-7 human breast cancer cell line. Proliferation elicited by Recombinant Human NRG1-1β1/HRG1-1β1 (40 ng/mL) is neutralized by increasing concentrations of Human ErbB3/Her3 Monoclonal Antibody (Catalog 10201-mhA24). The IC50 is typically 5.05-20.2 ng/mL. |
| Image 1 Alt Text | Human EEBB3/HER3 Blocking/Neutralization (B/N) 5595 |
| Image 1 URL | Source image |
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 3 |
| Description | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
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