| Catalog No. | Size | Price (USD) |
| 10139-MM39-50 | 50 µL | $147.96 |
| 10139-MM39-100 | 100 µL | $251.64 |
| 10139-MM39-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-1 beta Antibody, Mouse Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-1 beta |
| Immunogen | Recombinant Human IL1B/IL-1B/IL-1 beta Protein (Catalog#10139-HNAE) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1B/IL-1B/IL-1 beta (rh IL1B/IL-1B/IL-1 beta; Catalog#10139-HNAE; NP_000567.1; Ala117-Ser269). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #39 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IL-1 Antibody; Anti-IL-1B Antibody; Anti-IL1-BETA Antibody; Anti-IL1beta Antibody; Anti-IL1F2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human IL1b in human lung with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human IL1B/IL-1B/IL-1 beta Immunohistochemistry(IHC) 18018 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human IL1b in human lung with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human IL1B/IL-1B/IL-1 beta Immunohistochemistry(IHC) 18019 |
| Image 2 URL | Source image |
Background Information
| Full Name | interleukin 1, beta |
| Description | Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc). |
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