| Catalog No. | Size | Price (USD) |
| 10945-T48-50 | 50 µL | $147.96 |
| 10945-T48-100 | 100 µL | $251.64 |
| 10945-T48-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-10RB/IL-10R beta Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-10RB/IL-10R beta |
| Immunogen | Recombinant Human IL10RB / IL-10RB Protein (Catalog#10945-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human IL10RB / IL-10RB (rh IL10RB / IL-10RB; Catalog#10945-H08H; NP_000619.3; Met1-Ser220). IL10RB / IL-10RB specific IgG was purified by Human IL10RB / IL-10RB affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CDW210B Antibody; Anti-CRF2-4 Antibody; Anti-CRFB4 Antibody; Anti-D21S58 Antibody; Anti-D21S66 Antibody; Anti-IBD25 Antibody; Anti-IL-10R2 Antibody; Anti-IL-10RB Antibody
Image / Experimental Information
| Image 1 Description | Anti-IL10RB rabbit polyclonal antibody at 1:500 dilution. Lane A: Hela Membrane Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:37 kDa Observed band size:36 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Human IL10RB / IL-10RB Western blot (WB) 6625 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 10 receptor, beta |
| Description | Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins is required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn's disease and ulcerative colitis phenotypes. Crohn's disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. |
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