| Catalog No. | Size | Price (USD) |
| 10126-R024-50 | 50 µL | $177.58 |
| 10126-R024-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL1R1 |
| Immunogen | Recombinant Human IL-1R1 / CD121a Protein (Catalog#10126-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-1R1 / CD121a (rh IL-1R1 / CD121a; Catalog#10126-H08H; NP_000868.1; Met1-Thr332). |
| Source | Monoclonal Rabbit IgG Clone #024 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD121A Antibody; Anti-CRMO3 Antibody; Anti-D2S1473 Antibody; Anti-IL-1R-alpha Antibody; Anti-IL-1RT1 Antibody; Anti-IL1R Antibody; Anti-IL1RA Antibody; Anti-IL1RT1 Antibody; Anti-P80 Antibody
Background Information
| Full Name | interleukin 1 receptor, type I |
| Description | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
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