| Catalog No. | Size | Price (USD) |
| 10518-RP02-50 | 50 µL | $147.96 |
| 10518-RP02-100 | 100 µL | $251.64 |
| 10518-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-3R alpha/CD123 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-3R alpha/CD123 |
| Immunogen | Recombinant Human IL3RA / CD123 protein (Catalog#10518-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human IL3RA / CD123 (rh IL3RA / CD123; Catalog#10518-H08H; NP_002174.1; Met 1-Arg 305). IL3RA / CD123 specific IgG was purified by Human IL3RA / CD123 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD123 Antibody; Anti-hIL-3Ra Antibody; Anti-IL-3R-alpha Antibody; Anti-IL3R Antibody; Anti-IL3RA Antibody; Anti-IL3RAY Antibody; Anti-IL3RX Antibody; Anti-IL3RY Antibody
Background Information
| Full Name | interleukin 3 receptor, alpha (low affinity) |
| Description | Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity. |
| Related Pathways |
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| References |
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title: D-domain containing polypeptides and uses thereof
authors: David Lafleur; Jeffrey S. Swers; Justin Edwards
date: 2023-11-28
cited_by_count: 0
techniques: Binding Assay; Clone Assay; Expressing; Isolation; Sequencing; Variant Assay
bioz_score: 91
