| Catalog No. | Size | Price (USD) |
| 13520-RP01-100 | 100 µL | $147.96 |
| 13520-RP01-200 | 200 µL | $251.64 |
| 13520-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-IZUMO1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IZUMO1 |
| Immunogen | Recombinant Human IZUMO1 Protein (Catalog#13520-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human IZUMO1 (rh IZUMO1; Catalog#13520-H08H; AAH34769.1; Met1-Arg292). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IZUMO Antibody; Anti-MGC34799 Antibody; Anti-OBF Antibody
Background Information
| Full Name | izumo sperm-egg fusion 1 |
| Description | Izumo is a sperm membrane protein that plays a key role in the fusion in the mouse. It has an Immunoglobulin (Ig) domain and an N-terminal domain for which neither the functions nor homologous sequences are known. Up to now, there four members has an N-terminal domain with significant homology to the N-terminal domain of Izumo. We call this domain the Izumo domain. The four proteins are Izumo 1, 2, 3, and 4. Izumo domain possesses the ability to form dimers, whereas the transmembrane domain or the cytoplasmic domain, or both of Izumo 1 are required for the formation of multimers of a higher order. Izumo 1-3 are transmembrane proteins expressed specifically in the testis, and Izumo 4 is a soluble protein expressed in the testis and other tissues. Izumo 1, 3, and 4 formed protein complexes on sperm, Izumo 1 forming several larger complexes, and Izumo 3 and 4 forming a single larger complex. Izumo1 is essential for sperm-egg plasma membrane binding and fusion. |
| References |
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