| Catalog No. | Size | Price (USD) |
| 10140-MM01-50 | 50 µL | $147.96 |
| 10140-MM01-100 | 100 µL | $251.64 |
| 10140-MM01-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-L1CAM Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human L1CAM No cross-reactivity in ELISA with Human cell lysate (293 cell line) |
| Immunogen | Recombinant Human CD171 / N-CAML1 / L1CAM protein (Catalog#10140-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD171 / N-CAML1 / L1CAM (rh CD171 / N-CAML1 / L1CAM; Catalog#10140-H08H; NP_000416.1; Met 1-Glu 1120). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #01 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CAML1 Antibody; Anti-CD171 Antibody; Anti-HSAS Antibody; Anti-HSAS1 Antibody; Anti-HYCX Antibody; Anti-MASA Antibody; Anti-MIC5 Antibody; Anti-N-CAM-L1 Antibody; Anti-N-CAML1 Antibody; Anti-NCAM-L1 Antibody; Anti-S10 Antibody; Anti-SPG1 Antibody
Background Information
| Full Name | L1 cell adhesion molecule |
| Description | L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy. |
| References |
|
title: Isolation and quantification of L1CAM/ATP1A3/GAP43-positive extracellular vesicles on a EVArray biochip as potential biomarkers for Parkinson’s disease
authors: Yuwan Lin; Chunchen Liu; ...; Wenlong Zhang
journal: Microchemical Journal
date: 2026-07-24
doi: 10.1016/j.microc.2026.119186
cited_by_count: 0
bioz_score: 94
title: Hetero Sandwich Immunoassay as Tool to Probe the Composition of the Extracellular Vesicles Membranes: The Case Study of L1CAM Localization
authors: Helena Mateos; Antonia Mallardi; ...; Gerardo Palazzo
journal: ACS Omega
date: 2025-03-25
doi: 10.1021/acsomega.4c09363
pmcid: 11983164
cited_by_count: 0
techniques: Recombinant
bioz_score: 94
title: Unusual gold nanoparticle-antibody interactions
authors: Helena Mateos; Antonia Mallardi; ...; Gerardo Palazzo
journal: JCIS Open
date: 2023-10-01
doi: 10.1016/j.jciso.2023.100089
cited_by_count: 7
techniques: Recombinant
bioz_score: 94
