| Catalog No. | Size | Price (USD) |
| 11792-MM16-50 | 50 µL | $147.96 |
| 11792-MM16-100 | 100 µL | $251.64 |
| 11792-MM16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-M-CSF/CSF1 Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human M-CSF/CSF1 |
| Immunogen | Recombinant Human M-CSF/CSF-1 Protein (Catalog#11792-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human M-CSF/CSF-1 (rh M-CSF/CSF-1; Catalog#11792-H08H; P09603-1; Met1-Asn190). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #16 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CSF-1 Antibody; Anti-M-CSF Antibody; Anti-MCSF Antibody; Anti-MGC31930 Antibody; Anti-PG-M-CSF Antibody
Background Information
| Full Name | colony stimulating factor 1 (macrophage) |
| Description | Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression. |
| References |
|
title: Influenza Virus-like Particle-Based Hybrid Vaccine Containing RBD Induces Immunity against Influenza and SARS-CoV-2 Viruses
authors: Ramireddy Bommireddy; Shannon Stone; ...; Tokiko Watanabe
journal: Vaccines
date: 2022-06-14
pmid: 35746552
doi: 10.3390/vaccines10060944
pmcid: 9230705
cited_by_count: 15
techniques: Activity Assay; Binding Assay; Blocking Assay; Enzyme-linked Immunosorbent Assay; Expressing; FACS; Flow Cytometry; Functional Assay; HI Assay; Incubation; MANN-WHITNEY; Purification; Quantitative RT-PCR; Western Blot
bioz_score: 90
title: Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model
authors: Hui Wang; Lihua Mo; ...; Zhigang Liu
journal: Scientific Reports
date: 2017-02-27
pmid: 28240301
doi: 10.1038/srep43322
pmcid: 5327411
cited_by_count: 4
techniques: Enzyme-linked Immunosorbent Assay
bioz_score: 90
