| Catalog No. | Size | Price (USD) |
| 100953-T10-50 | 50 µL | $147.96 |
| 100953-T10-100 | 100 µL | $251.64 |
| 100953-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Mouse, Rat (Species predicted to react based on 100% sequence homology) |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Human MAP2K5 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MAP2K5, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-HsT17454 Antibody; Anti-MAPKK5 Antibody; Anti-MEK5 Antibody; Anti-MKK5 Antibody; Anti-PRKMK5 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of MAP2K5 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human MAP2K5 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to nucleus. |
| Image 1 Alt Text | Human MAP2K5/MEK5 Immunohistochemistry(IHC) 2823 |
| Image 1 URL | Source image |
| Image 2 Description | Immunofluorescence staining of MAP2K5 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human MAP2K5 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to nucleus. |
| Image 2 Alt Text | Human MAP2K5/MEK5 Immunohistochemistry(IHC) 3915 |
| Image 2 URL | Source image |
| Image 3 Description | Immunofluorescence staining of MAP2K5 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human MAP2K5 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to nucleus. |
| Image 3 Alt Text | Human MAP2K5/MEK5 Immunohistochemistry(IHC) 3916 |
| Image 3 URL | Source image |
Background Information
| Full Name | mitogen-activated protein kinase kinase 5 |
| Description | MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5, also known as MEK5) is a Protein Coding gene. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. The signal cascade mediated by this kinase is involved in growth factor-stimulated cell proliferation and muscle cell differentiation. 4 alternatively spliced human isoforms have been reported. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. SNP rs1026732 in MAP2K5/SKOR1 was significantly associated with restless legs syndrome (RLS). RLS is considered a genetic disease and, following a genome-wide association study conducted in 2007, the MAP2K5 gene has been regarded as the promising candidate gene for RLS. |
| Related Pathways |
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