| Catalog No. | Size | Price (USD) |
| 10467-MM05-1 | 1 mL | $1,377.43 |
| 10467-MM05-20 | 20 µL | $88.87 |
| 10467-MM05-50 | 50 µL | $147.96 |
| 10467-MM05-100 | 100 µL | $251.64 |
| 10467-MM05-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MMP-3 Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol), ELISA(Det) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MMP-3 No cross-reactivity in ELISA with Human MMP1 Human MMP8 Human MMP9 E.coli cell lysate |
| Immunogen | Recombinant Human MMP-3 protein (Catalog#10467-HNAE) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MMP-3 (rh MMP-3; Catalog#10467-HNAE; AAA36321.1; Tyr 18-Thr 272). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #05 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CHDS6 Antibody; Anti-MMP-3 Antibody; Anti-SL-1 Antibody; Anti-STMY Antibody; Anti-STMY1 Antibody; Anti-STR1 Antibody
Background Information
| Full Name | matrix metallopeptidase 3 |
| Description | Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. Also, MMP3 can active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion. |
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