| Catalog No. | Size | Price (USD) |
| 110587-R0060-20 | 20 µL | $103.53 |
| 110587-R0060-100 | 100 µL | $296.07 |
General Information
| Product name | Phospho-Met (Tyr1234, 1235) Antibody, Rabbit MAb |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human Predicted to React with: Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Rabbit |
| Specificity | Human Species predicted to react based on 100% sequence homology: Mouse, Rat, Cynomolgus, Rabbit |
| Immunogen | A synthetic peptide corresponding to residues around (Tyr1234, 1235) of Human Phospho-Met |
| Preparation | This antibody was obtained from a rabbit immunized with a synthetic peptide corresponding to residues around (Tyr1234, 1235) of Human Phospho-Met. |
| Source | Monoclonal Rabbit IgG Clone #0060 |
| Purification | Protein A |
| Formulation | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DA11 Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody
Image / Experimental Information
| Image 1 Description | Western blot analysis of extracts from serum-starved A549, untreated (line A); treated with HGF(Cat# 10463-HNAS) (50 ng/mL, 5min; +) (line B); treated with HGF and λ-phosphatase (Cat# L01-20U) (line C) using Phospho-Met(Tyr1234, 1235) rabbit monoclonal Antibody (Cat# 110587-R0060) at 1:1000 dilution. (Validation Experiment) |
| Image 1 Alt Text | Human c-MET/HGFR Western blot (WB) 42712 |
| Image 1 URL | Source image |
| Image 2 Description | Western blot analysis of extracts from serum-starved A549, untreated (line A); treated with HGF(Cat# 10463-HNAS) (50 ng/mL, 5min; +) (line B); treated with HGF and λ-phosphatase (Cat# L01-20U) (line C) using Phospho-Met(Tyr1234, 1235) rabbit monoclonal Antibody (Cat# 110587-R0060) at 1:1000 dilution. (Validation Experiment) |
| Image 2 Alt Text | Human HGF Western blot (WB) 42711 |
| Image 2 URL | Source image |
Background Information
| Full Name | MET proto-oncogene, receptor tyrosine kinase |
| Description | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer. |
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