| Catalog No. | Size | Price (USD) |
| 100972-T32-50 | 50 µL | $147.96 |
| 100972-T32-100 | 100 µL | $251.64 |
| 100972-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MSH5 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Mouse (Species predicted to react based on 100% sequence homology) |
| Immunogen | A synthetic peptide corresponding to the center region of the human MSH5 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the human MSH5, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-G7 Antibody; Anti-MUTSH5 Antibody; Anti-NG23 Antibody; Anti-POF13 Antibody; Anti-SPGF74 Antibody
Image / Experimental Information
| Image 1 Description | Anti-MSH5 rabbit polyclonal antibody at 1:500 dilution Lane A: HL-60 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:93 kDa Observed band size:93 kDa |
| Image 1 Alt Text | Human MSH5 Western blot (WB) 6536 |
| Image 1 URL | Source image |
Background Information
| Full Name | mutS homolog 5 |
| Description | MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. This protein binds to mtDNA and interacts with the Twinkle helicase and the DNA polymerase gamma. hMSH5 stimulates mtDNA repair in response to DNA damage induced by oxidative stress. Since MSH5 encodes a protein homologous to DNA mismatch recognition proteins, mismatch repair genes are frequently mutated in cancers cells and, like mismatch repair genes, MSH5 is highly conserved from yeast to human, this observation suggests novel mechanisms of chemotherapeutic drug resistance that may occur in certain human cancer patients. The human MSH5 gene consists of 25 exons and spans at least 12 kb of genomic DNA, while the C. elegans gene comprises 17 exons distributed over at least 5.8 kb. |
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