| Catalog No. | Size | Price (USD) |
| 10357-MM02-1 | 1 mL | $1,377.43 |
| 10357-MM02-20 | 20 µL | $118.49 |
| 10357-MM02-50 | 50 µL | $147.96 |
| 10357-MM02-100 | 100 µL | $340.51 |
| 10357-MM02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IL-18BP Antibody, Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol), ELISA(Cap) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-18BP |
| Immunogen | Human cell-derived rhIL18BPa (Catalog#10357-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL18BPa N-terminal domain (rhIL18BPa; Catalog#10357-H08H; NP_001034748.1; Met1-Gly194). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG2b Clone #7A11C11G1 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FVH Antibody; Anti-IL18BPa Antibody
Background Information
| Full Name | interleukin 18 binding protein |
| Description | Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases. |
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