| Catalog No. | Size | Price (USD) |
| 12123-T24-50 | 50 µL | $147.96 |
| 12123-T24-100 | 100 µL | $251.64 |
| 12123-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MUC-1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MUC-1 |
| Immunogen | Recombinant Human MUC-1 / Mucin 1 / CD227 protein |
| Preparation | Produced in rabbits immunized with purified, recombinant Human MUC-1 / Mucin 1 / CD227 (rh MUC-1 / Mucin 1 / CD227;NP_001018016.1; Met1-Gly167). MUC-1 / Mucin 1 / CD227 specific IgG was purified by Human MUC-1 / Mucin 1 / CD227 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ADMCKD Antibody; Anti-ADMCKD1 Antibody; Anti-ADTKD2 Antibody; Anti-CA 15-3 Antibody; Anti-Ca15-3 Antibody; Anti-CD227 Antibody; Anti-EMA Antibody; Anti-H23AG Antibody; Anti-KL-6 Antibody; Anti-MAM6 Antibody; Anti-MCD Antibody; Anti-MCKD Antibody; Anti-MCKD1 Antibody; Anti-MUC-1 Antibody; Anti-MUC-1/SEC Antibody; Anti-MUC-1/X Antibody; Anti-MUC1/ZD Antibody; Anti-PEM Antibody; Anti-PEMT Antibody; Anti-PUM Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human MUC1 in human ovarian cancer with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Human MUC1/Mucin 1/CD227 Immunohistochemistry(IHC) 3879 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human MUC1 in human ovarian cancer with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). |
| Image 2 Alt Text | Human MUC1/Mucin 1/CD227 Immunohistochemistry(IHC) 3880 |
| Image 2 URL | Source image |
Background Information
| Full Name | mucin 1, cell surface associated |
| Description | Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach, and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized, and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC, and NF-kappa-B pathways. In the activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
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